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Raltegravir Dosage

Medically reviewed by Drugs.com. Last updated on Jul 27, 2023.

Applies to the following strengths: 400 mg; 25 mg; 100 mg; 600 mg

Usual Adult Dose for HIV Infection

Therapy-naive patients or patients virologically-suppressed on an initial regimen of the 400 mg film-coated tablets twice a day:
600 mg film-coated tablets: 1200 mg orally once a day
400 mg film-coated tablets: 400 mg orally twice a day

Therapy-experienced patients:
400 mg film-coated tablets: 400 mg orally twice a day

Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

Usual Adult Dose for Occupational Exposure

US Public Health Service Working Group Recommendations:
400 mg film-coated tablets: 400 mg orally twice a day
Duration of therapy: 28 days, if tolerated

Comments:

Usual Adult Dose for Nonoccupational Exposure

US CDC Recommendations:
400 mg film-coated tablets: 400 mg orally twice a day
Duration of therapy: 28 days

Comments:

Usual Pediatric Dose for HIV Infection

ORAL SUSPENSION:
Full-Term Neonates (Birth to 4 Weeks [28 Days] of Age):
Birth to 1 week:


1 to 4 weeks:

Pediatric Patients At Least 4 Weeks of Age:

CHEWABLE TABLETS:
Pediatric Patients At Least 4 Weeks of Age:

400 MG FILM-COATED TABLETS:

600 MG FILM-COATED TABLETS:

Maximum dose:

Comments:

Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

Usual Pediatric Dose for Nonoccupational Exposure

US CDC Recommendations:
ORAL SUSPENSION:
Pediatric Patients At Least 4 Weeks of Age:


CHEWABLE TABLETS:
Pediatric Patients At Least 4 Weeks of Age:

400 MG FILM-COATED TABLETS:

Maximum dose:

Duration of therapy: 28 days

Comments:

Renal Dose Adjustments

Any degree of renal dysfunction: No adjustment recommended.

Liver Dose Adjustments

400 mg film-coated tablets, chewable tablets, oral suspension:


600 mg film-coated tablets:

Dose Adjustments

Concomitant rifampin:
400 mg film-coated tablets:

Precautions

CONTRAINDICATIONS: None

This drug is not recommended for use in preterm neonates or pediatric patients weighing less than 2 kg.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Comments:

Other Comments

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

General:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.