Rabeprazole Dosage

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Usual Adult Dose for Duodenal Ulcer

20 mg orally once a day, after the morning meal. The usual duration of therapy is four weeks in most patients, however, some patients may require additional therapy to achieve ulcer healing.

Usual Adult Dose for Erosive Esophagitis

20 mg orally once a day, after the morning meal. Therapy should be continued for 4 to 8 weeks.

Usual Adult Dose for Gastric Ulcer

20 mg orally once a day, after the morning meal. Therapy should be continued for 4 to 8 weeks.

Usual Adult Dose for Duodenal Ulcer Prophylaxis

20 mg orally once a day, after the morning meal. Studies evaluating maintenance therapy for duodenal ulcers have not extended beyond 12 months.

Usual Adult Dose for Gastroesophageal Reflux Disease

20 mg orally once a day, after the morning meal. Therapy should be continued for 4 to 8 weeks.

Maintenance therapy may be required in some patients as part of relapse of erosive esophagitis or ulcerative gastroesophageal reflux disease is not uncommon. Studies have shown rabeprazole 20 mg orally once a day for 52 weeks to provide 86% to 90% maintenance of healing.

Usual Adult Dose for Helicobacter pylori Infection

Three drug regimen: rabeprazole 20 mg, amoxicillin 1000 mg, and clarithromycin 500 mg orally two times daily with morning and evening meals for 7 days.

In triple therapy studies, rabeprazole 20 mg was combined with either clarithromycin 500 mg and metronidazole 400 mg, or amoxicillin 1000 mg and clarithromycin 500 mg, or amoxicillin 1000 mg and metronidazole 400 mg each given orally twice a day for 7 days. These combinations provided eradication rates of 100%, 95%, and 90% respectively.

In dual therapy studies, rabeprazole 20 mg was combined with clarithromycin 500 mg orally twice a day for 7 days which provided an eradication rate of 63%.

Usual Adult Dose for Zollinger-Ellison Syndrome

Initial: 60 mg orally once a day, after the morning meal.

Maintenance: Doses up to 100 mg orally once a day or 60 mg orally twice a day have been administered. Patients have been treated continuously for up to one year.

Usual Pediatric Dose for Gastroesophageal Reflux Disease

12 years or above: 20 mg orally once a day, after the morning meal. Therapy should be continued for 8 weeks.

1 to 11 years olds:
Less than 15 kg: 5 mg oral sprinkle capsule once daily with option of increasing to 10 mg orally once daily.
15 kg or greater: 10 mg oral sprinkle capsule once daily
Duration: For up to 12 weeks

Comments:
-Do not crush or chew the sprinkle capsules
-Open sprinkle capsule and empty contents on a small amount of soft food or empty into a small amount of liquid
-Take the whole dose of the sprinkle capsule in food or liquid within 15 minutes of preparation

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Mild to moderate hepatic impairment: No adjustment recommended
Severe hepatic impairment: Use with caution

Precautions

Use of rabeprazole therapy in adolescent patients 12 years of age and above for short-term treatment of GERD is supported by extrapolation of results from adequate and well-controlled trials that supported the approval of rabeprazole for adults and safety and pharmacokinetic studies performed in adolescent patients. The safety and efficacy of rabeprazole for the treatment of GERD patients less than 12 years of age have not been established. The safety and efficacy of rabeprazole for other uses have not been established in pediatric patients. In a multicenter, randomized, open-label, parallel-group study, 111 adolescents individuals 12 to 16 years of age with a clinical diagnosis of symptomatic GERD or suspected or endoscopically proven GERD were randomized and treated with either rabeprazole 10 mg or rabeprazole 20 mg once daily for up to 8 weeks for the evaluation of safety and efficacy. The adverse event profile in adolescent patients was similar to that of adults. There were no adverse reactions reported in these studies that were not previously observed in adult patients.

Dialysis

Data not available

Other Comments

Rabeprazole should be swallowed whole and not chewed, crushed, or split.

Rabeprazole may be taken with or without food.

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