Skip to Content

Protriptyline Dosage

Applies to the following strength(s): 5 mg ; 10 mg

The information at is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Geriatric Dose for:

Additional dosage information:

Usual Adult Dose for Depression

15 to 40 mg orally per day divided into three or four doses
Maximum dose: 60 mg orally per day

-Dosage increments should be made in the morning dose.

Use: Treatment of symptoms of mental depression in patients who are under close medical supervision

Usual Geriatric Dose for Depression

5 mg orally 3 times a day, increasing gradually if necessary

-Cardiovascular status should be monitored closely if daily dosage exceeds 20 mg.
-Dosage reductions may be required if minor adverse reactions develop. However, prompt discontinuation of the drug is necessary if major adverse reactions or hypersensitivity reactions occur.
-Once the desired therapeutic effects are achieved, dosage should be reduced to the smallest amount that will maintain relief of symptoms.

Use: Treatment of symptoms of mental depression in patients who are under close medical supervision

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available


Suicidality and Antidepressant Drugs
-Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of this drug or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need.
-Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24. There was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older.
-Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber.
-This drug is not approved for use in pediatric patients.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

-Psychiatric: Patients should be monitored for clinical worsening and emergence of suicidal thoughts.

Patient advice:
-Somnolence has been reported. Caution in driving and operating machinery is recommended until the individual response to the drug has been determined.