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Propylthiouracil Dosage

Applies to the following strength(s): 50 mg

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Hyperthyroidism

-INITIAL DOSE: 100 mg orally every 8 hours (300 mg daily); some patients may require 400 mg orally daily in 3 divided doses; rarely, a patient may require 600 to 900 mg orally daily in 3 divided doses
-MAINTENANCE DOSE: 100 to 150 mg orally daily in 3 equally divided doses every 8 hours

Use: In patients with Graves' disease with hyperthyroidism or toxic multinodular goiter who are intolerant of methimazole and for whom surgery or radioactive iodine therapy is not an appropriate treatment option

Usual Adult Dose for Thyroid Storm

-INITIAL DOSE: 100 mg orally every 8 hours (300 mg daily); some patients may require 400 mg orally daily in 3 divided doses; rarely, a patient may require 600 to 900 mg orally daily in 3 divided doses
-MAINTENANCE DOSE: 100 to 150 mg orally daily in 3 equally divided doses every 8 hours

Use: To ameliorate symptoms of hyperthyroidism in preparation for thyroidectomy or radioactive iodine therapy in patients who are intolerant of methimazole

Usual Pediatric Dose for Hyperthyroidism

This drug is generally not recommended for use in pediatric patients except when other therapies are not an option.
SUGGESTED INITIAL DOSE:
-Patients younger than 6 years: Not recommended
-Patients 6 years or older: 50 mg orally daily with careful upward titration based on clinical response and evaluation of TSH and free T4 levels

Comment:
-Although cases of severe liver injury have been reported with doses as low as 50 mg per day, most cases were associated with doses of 300 mg per day and higher.

Use: Hyperthyroidism

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

Precautions

US BOXED WARNINGS:
-Severe liver injury and acute liver failure, in some cases fatal, have been reported in both adult and pediatric patients treated with this drug. Some of these cases required liver transplantation.
-This drug should be reserved for patients who cannot tolerate methimazole and in whom radioactive iodine therapy or surgery are not appropriate treatments for the management of hyperthyroidism.
-This drug may be the treatment of choice when an antithyroid drug is indicated during or just prior to the first trimester of pregnancy.

Safety and efficacy have not been established in patients younger than 6 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Monitoring:
-Thyroid function
-International Normalized Ratio (INR)

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