Propantheline Dosage

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Usual Adult Dose for:

Usual Geriatric Dose for:

Additional dosage information:

Usual Adult Dose for Peptic Ulcer

Adjunctive therapy:
Initial dose: 15 mg orally taken 30 minutes before each meal and 30 mg orally at bedtime (a total of 75 mg/day)

Patients with mild manifestations and patients of small stature may be given 7.5 mg orally 3 times a day, taken 30 minutes before each meal.

Usual Geriatric Dose for Peptic Ulcer

Adjunctive therapy:
Initial dose: 7.5 mg orally 3 times a day, taken 30 minutes before each meal

Renal Dose Adjustments

The manufacturer recommends caution when administering this drug to patients with renal disease.

Liver Dose Adjustments

The manufacturer recommends caution when administering this drug to patients with hepatic disease.

Dose Adjustments

Subsequent dosage adjustment should be made according to the patient's individual response and tolerance.

Precautions

Propantheline is contraindicated in patients with glaucoma, obstructive disease of the gastrointestinal tract, obstructive uropathy, intestinal atony of the elderly or debilitated patient, severe ulcerative colitis or toxic megacolon complicating ulcerative colitis, unstable cardiovascular adjustment in acute hemorrhage, and myasthenia gravis.

Propantheline should be used with caution in the elderly and in all patients with autonomic neuropathy, hyperthyroidism, coronary heart disease, congestive heart failure, cardiac tachyarrhythmias, hypertension, or hiatal hernia associated with reflux esophagitis.

Because gastrointestinal antispasmodics are highly anticholinergic drugs, propantheline meets Beers criteria as a medication that is potentially inappropriate for use in older adults.

With overdose, a curare-like action may occur, characterized by muscular weakness and possible paralysis.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

Propantheline may cause drowsiness or blurred vision. Patients should be cautioned regarding activities requiring mental alertness (such as operating a motor vehicle or other machinery or performing hazardous work) while taking this drug.

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