Prochlorperazine Dosage

This dosage information may not include all the information needed to use Prochlorperazine safely and effectively. See additional information for Prochlorperazine.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Nausea/Vomiting

Severe nausea and vomiting:
Tablet: 5 to 10 mg 3 to 4 times a day.

Capsule: 15 mg on arising or 10 mg capsule every 12 hours. Daily oral doses above 40 mg should be used only in resistant cases.

Rectal: 25 mg twice a day.

IM: 5 to 10 mg. If necessary, repeat every 3 to 4 hours. Total IM dosage should not exceed 40 mg/day.

IV: 2 1/2 to 10 mg by slow IV injection or infusion at a rate not to exceed 5 mg/min.
A single dose of the drug should not exceed 10 mg. Total IV dosage should not exceed 40 mg/day.

Adult surgery (for severe nausea and vomiting):
IM: 5 to 10 mg injection 1 to 2 hours before induction of anesthesia (repeat once in 30 minutes, if necessary), or to control acute symptoms during and after surgery (repeat once if necessary).

IV: 5 to 10 mg as a slow IV injection or infusion 15 to 30 minutes before induction of anesthesia, or to control acute symptoms during or after surgery. Repeat once if necessary. A single dose of the drug should not exceed 10 mg. The rate of administration should not exceed 5 mg/minute.

Usual Adult Dose for Anxiety

Non-psychotic anxiety:
Tablet: 5 mg 3 to 4 times a day.

Capsule: 15 mg on arising or 10 mg every 12 hours.

Do not administer in doses of more than 20 mg/day or for longer than 12 weeks.

Usual Adult Dose for Psychosis

Mild psychotic disorders:
5 to 10 mg orally 3 to 4 times a day.

Moderate to severe psychotic disorders:
Oral: 10 mg orally 3 to 4 times a day. Increase dosage every 2 to 3 days until symptoms are controlled or side effects become bothersome. Some patients respond satisfactorily on 50 to 75 mg/day. In more severe disturbances, optimum dosage is usually 100 to 150 mg/day.

IM: For immediate control of severely disturbed adults, inject an initial dose of 10 to 20 mg deeply into the upper outer quadrant of the buttock. Many patients respond shortly after the first injection. If necessary, repeat the initial dose every 2 to 4 hours (or, in resistant cases, every hour) to gain control of the patient. More than 3 to 4 doses are seldom necessary. After control is achieved, switch patient to an oral form of the drug at the same dosage level or higher. If, in rare cases, parenteral therapy is needed for a prolonged period, give 10 to 20 mg every 4 to 6 hours.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Dosage should be increased more gradually in debilitated, or elderly patients.
Children seem more prone to develop extrapyramidal reactions, even on moderate doses. Therefore, use lowest effective dosage.

Precautions

Hypotension is a possibility if the drug is given by IV injection or infusion. Dosages in the lower range are sufficient for most elderly patients. Since they appear to be more susceptible to hypotension and neuromuscular reactions, such patients should be observed closely. Dosage should be tailored to the individual, response carefully monitored and dosage adjusted accordingly.

Dialysis

Data not available

Other Comments

Total parenteral dosage should not exceed 40 mg/day.

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