Pentostatin Dosage
This dosage information may not include all the information needed to use Pentostatin safely and effectively. See additional information for Pentostatin.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hairy Cell Leukemia
For use as single agent treatment for both untreated and alpha interferon refractory hairy cell leukemia patients with active disease (as defined by clinically significant anemia, neutropenia, thrombocytopenia, or disease related symptoms):
4 mg/m2 every other week. (Higher doses are not recommended.)
Renal Dose Adjustments
There are insufficient data to recommend a starting or a subsequent dose for patients with impaired renal function (creatinine clearance <60 mL/min)
Liver Dose Adjustments
Data not available.
Precautions
Drug treatment should be withheld in patients with severe rash, and withheld or discontinued in patients showing evidence of nervous system toxicity. Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
Dialysis
Data not available.
Other Comments
It is recommended that patients receive hydration with 500 to 1,000 mL of 5% dextrose in 0.5 normal saline or equivalent before pentostatin administration. An additional 500 mL of 5% dextrose or equivalent should be administered after pentostatin is given.
The optimal duration of treatment has not been determined. In the absence of major toxicity and with observed continuing improvement, the patient should be treated until a complete response has been achieved. Although not a requirement, the administration of two additional doses has been recommended following the achievement of a complete response.
