Pentostatin Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hairy Cell Leukemia

For use as single agent treatment for both untreated and alpha interferon refractory hairy cell leukemia patients with active disease (as defined by clinically significant anemia, neutropenia, thrombocytopenia, or disease related symptoms):
4 mg/m2 every other week. (Higher doses are not recommended.)

Renal Dose Adjustments

There are insufficient data to recommend a starting or a subsequent dose for patients with impaired renal function (creatinine clearance <60 mL/min)

Liver Dose Adjustments

Data not available.

Precautions

Drug treatment should be withheld in patients with severe rash, and withheld or discontinued in patients showing evidence of nervous system toxicity. Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available.

Other Comments

It is recommended that patients receive hydration with 500 to 1,000 mL of 5% dextrose in 0.5 normal saline or equivalent before pentostatin administration. An additional 500 mL of 5% dextrose or equivalent should be administered after pentostatin is given.

The optimal duration of treatment has not been determined. In the absence of major toxicity and with observed continuing improvement, the patient should be treated until a complete response has been achieved. Although not a requirement, the administration of two additional doses has been recommended following the achievement of a complete response.

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