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Pegloticase Dosage

Medically reviewed by Drugs.com. Last updated on Aug 25, 2022.

Applies to the following strengths: 8 mg/mL

Usual Adult Dose for Gout

8 mg via IV infusion every 2 weeks

Comment:


Use: For the treatment of chronic gout in patients who are refractory to conventional therapy (e.g., patients who have failed to normalize serum uric acid and whose signs/symptoms are inadequately controlled with xanthine oxidase inhibitors at the maximum medically appropriate dose or for whom these drugs are contraindicated)

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Data not available

Dose Adjustments

To Decrease Risk of Anaphylaxis and Infusion Reactions:

Precautions

US BOXED WARNINGS: ANAPHYLAXIS AND INFUSION REACTIONS:

GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD) DEFICIENCY ASSOCIATED HEMOLYSIS AND METHEMOGLOBINEMIA:

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Reconstitution/preparation techniques:

Storage requirements:
Prior to dilution: Store in carton, protect from light, keep under refrigeration (2C to 8C [36F to 46F]) at all times; do not shake or freeze.

IV compatibility:

General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.