Papain / Urea Topical Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Dermatologic Lesion

Papain-urea 830,000 units/g-10% topical ointment or foam:
Irrigate and cleanse the lesion with isotonic saline or a mild cleansing solution 1 or 2 times daily. After cleansing, apply ointment directly to lesion and cover with appropriate dressing.

Papain-urea 650,000 units/g-10% topical ointment:
Irrigate and cleanse the lesion with isotonic saline or a mild cleansing solution 1 or 2 times daily. After cleansing, apply ointment directly to lesion and cover with appropriate dressing.

Papain-urea 1,100,000 units/g-10% topical ointment:
Irrigate and cleanse the lesion with isotonic saline or a mild cleansing solution 1 or 2 times daily. After cleansing, apply ointment directly to lesion and cover with appropriate dressing.

Papain-urea 10%-10% topical spray:
Irrigate and cleanse the lesion with isotonic saline or a mild cleansing solution 1 or 2 times daily. After cleansing, spray 1 to 2 inches from the affected area until the wound is completely covered. Apply dressing of choice.

Papain-urea-chlorophyllin copper complex sodium 10%-10%-0.5%:
Irrigate and cleanse the lesion with isotonic saline or a mild cleansing solution 1 or 2 times daily. After cleansing, spray 2 to 3 inches from the affected area until the wound is completely covered. Apply dressing of choice. While application 1 to 2 times daily is preferred, longer intervals of up to 2 to 3 days have been reported.

Usual Adult Dose for Burns - External

Papain-urea 830,000 units/g-10% topical ointment or foam:
Irrigate and cleanse the lesion with isotonic saline or a mild cleansing solution 1 or 2 times daily. After cleansing, apply ointment directly to lesion and cover with appropriate dressing.

Papain-urea 650,000 units/g-10% topical ointment:
Irrigate and cleanse the lesion with isotonic saline or a mild cleansing solution 1 or 2 times daily. After cleansing, apply ointment directly to lesion and cover with appropriate dressing.

Papain-urea 1,100,000 units/g-10% topical ointment:
Irrigate and cleanse the lesion with isotonic saline or a mild cleansing solution 1 or 2 times daily. After cleansing, apply ointment directly to lesion and cover with appropriate dressing.

Papain-urea 10%-10% topical spray:
Irrigate and cleanse the lesion with isotonic saline or a mild cleansing solution 1 or 2 times daily. After cleansing, spray 1 to 2 inches from the affected area until the wound is completely covered. Apply dressing of choice.

Papain-urea-chlorophyllin copper complex sodium 10%-10%-0.5%:
Irrigate and cleanse the lesion with isotonic saline or a mild cleansing solution 1 or 2 times daily. After cleansing, spray 2 to 3 inches from the affected area until the wound is completely covered. Apply dressing of choice. While application 1 to 2 times daily is preferred, longer intervals of up to 2 to 3 days have been reported.

Usual Adult Dose for Wound Debridement

Papain-urea 830,000 units/g-10% topical ointment or foam:
Irrigate and cleanse the lesion with isotonic saline or a mild cleansing solution 1 or 2 times daily. After cleansing, apply ointment directly to lesion and cover with appropriate dressing.

Papain-urea 650,000 units/g-10% topical ointment:
Irrigate and cleanse the lesion with isotonic saline or a mild cleansing solution 1 or 2 times daily. After cleansing, apply ointment directly to lesion and cover with appropriate dressing.

Papain-urea 1,100,000 units/g-10% topical ointment:
Irrigate and cleanse the lesion with isotonic saline or a mild cleansing solution 1 or 2 times daily. After cleansing, apply ointment directly to lesion and cover with appropriate dressing.

Papain-urea 10%-10% topical spray:
Irrigate and cleanse the lesion with isotonic saline or a mild cleansing solution 1 or 2 times daily. After cleansing, spray 1 to 2 inches from the affected area until the wound is completely covered. Apply dressing of choice.

Papain-urea-chlorophyllin copper complex sodium 10%-10%-0.5%:
Irrigate and cleanse the lesion with isotonic saline or a mild cleansing solution 1 or 2 times daily. After cleansing, spray 2 to 3 inches from the affected area until the wound is completely covered. Apply dressing of choice. While application 1 to 2 times daily is preferred, longer intervals of up to 2 to 3 days have been reported.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Papain-urea is not for ophthalmic use and should not be used on area surrounding the eye(s).

Hydrogen peroxide, the salts of heavy metals such as lead, silver, and mercury, and the use of topical medications containing the salts of heavy metals may inactivate the enzymatic action of papain.

The periwound area should be protected with a skin protectant to prevent or reduce maceration and irritation that may be caused by drainage from the wound.

Dialysis

Data not available

Other Comments

Crosshatching of eschar may be necessary prior to application to improve penetration of papain-urea.

The wound should be irrigated prior to each dressing change to remove any accumulation of liquefied necrotic material.

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