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Oncaspar Dosage

Generic name: pegaspargase
Dosage form: injection, solution

This dosage information does not include all the information needed to use Oncaspar safely and effectively. See full prescribing information for Oncaspar.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Recommended Dose

The recommended dose of Oncaspar® is 2,500 International Units/m2 intramuscularly or intravenously. Oncaspar® should be administered no more frequently than every 14 days.

Instructions for Administration

When Oncaspar® is administered intramuscularly, the volume at a single injection site should be limited to 2 mL. If the volume to be administered is greater than 2 mL, multiple injection sites should be used. Oncaspar® does not contain a preservative. Use only one dose per vial; discard unused product.

When administered intravenously, Oncaspar® should be given over a period of 1 to 2 hours in 100 mL of sodium chloride or dextrose injection 5%, through an infusion that is already running. After the solution is diluted for intravenous use, the solution should be used immediately. If immediate use is not possible, the diluted solution should be stored refrigerated at 2°C to 8°C (36°F to 46°F). Storage after dilution should not exceed 48 hours from the time of preparation to completion of administration. Protect infusion bags from direct sunlight.

Preparation and Handling Precautions

Do not administer Oncaspar® if drug has been:

  • frozen
  • stored at room temperature 15° - 25°C (59° - 77°F) for more than 48 hours
  • shaken or vigorously agitated [see How Supplied/Storage and Handling (16)]

Parenteral drug products should be inspected visually for particulate matter, cloudiness, or discoloration prior to administration, whenever solution and container permit. If any of these are present, discard the vial.

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