Noroxin Dosage

Generic name: norfloxacin
Dosage form: tablet, film coated

This dosage information does not include all the information needed to use Noroxin safely and effectively. See full prescribing information for Noroxin.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Tablets NOROXIN should be taken at least one hour before or at least two hours after a meal or ingestion of milk and/or other dairy products. Multivitamins, other products containing iron or zinc, antacids containing magnesium and aluminum, sucralfate, or Videx® (Didanosine), chewable/buffered tablets or the pediatric powder for oral solution, should not be taken within 2 hours of administration of norfloxacin. Tablets NOROXIN should be taken with a glass of water. Patients receiving NOROXIN should be well hydrated (see PRECAUTIONS).

Normal Renal Function

The recommended daily dose of NOROXIN is as described in the following chart:

Infection


Description


Unit
Dose


Frequency


Duration


Daily
Dose


Urinary Tract

Uncomplicated UTI's (cystitis) due to E. coli,
K. pneumoniae, or P. mirabilis


400 mg

q12h

3 days

800 mg

Uncomplicated UTI's
due to other indicated organisms


400 mg

q12h

7-10
days

800 mg

Complicated UTI's


400 mg

q12h

10-21
days

800 mg

Sexually Transmitted Diseases


Uncomplicated Gonorrhea


800 mg

single
dose

1 day

800 mg

Prostatitis

Acute or Chronic


400 mg

q12h

28 days

800 mg

Renal Impairment

NOROXIN may be used for the treatment of urinary tract infections in patients with renal insufficiency. In patients with a creatinine clearance rate of 30 mL/min/1.73 m2 or less, the recommended dosage is one 400-mg tablet once daily for the duration given above. At this dosage, the urinary concentration exceeds the MICs for most urinary pathogens susceptible to norfloxacin, even when the creatinine clearance is less than 10 mL/min/1.73 m2.

When only the serum creatinine level is available, the following formula (based on sex, weight, and age of the patient) may be used to convert this value into creatinine clearance. The serum creatinine should represent a steady state of renal function.

Males:       (weight in kg) × (140 − age)
                   (72) × serum creatinine (mg/100 mL)

Females:   (0.85) × (above value)

Elderly

Elderly patients being treated for urinary tract infections who have a creatinine clearance of greater than 30 mL/min/1.73 m2 should receive the dosages recommended under Normal Renal Function.

Elderly patients being treated for urinary tract infections who have a creatinine clearance of 30 mL/min/1.73 m2 or less should receive 400 mg once daily as recommended under Renal Impairment.

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