Norepinephrine Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypotension

Initial dose: 2 to 4 mcg/min
Maintenance dose: Adjust the rate for a low normal blood pressure (usually 80 to 100 mm Hg systolic). The average maintenance dose ranges from 1 to 12 mcg/min.

Usual Adult Dose for Shock

Initial dose: 2 to 4 mcg/min
Maintenance dose: Adjust the rate for a low normal blood pressure (usually 80 to 100 mm Hg systolic). The average maintenance dose ranges from 1 to 12 mcg/min.

Dose Adjustments

Great individual variation occurs in the dose required to attain and maintain an adequate blood pressure. In all cases, dosage of norepinephrine should be titrated according to the response of the patient. Occasionally much larger or even enormous daily doses (as high as 68 mg base or 17 ampuls) may be necessary if the patient remains hypotensive, but occult blood volume depletion should always be suspected and corrected when present. Central venous pressure monitoring is usually helpful in detecting and treating this situation.

Other Comments

In previously hypertensive patients, it is recommended that the blood pressure should be raised no higher than 40 mm Hg below the preexisting systolic pressure.

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