Nitroprusside Dosage

This dosage information may not include all the information needed to use Nitroprusside safely and effectively. See additional information for Nitroprusside.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypertensive Emergency

Initial dose: 0.3 mcg/kg/min IBW administered by continuous IV infusion.
Maintenance dose: The dose may be titrated upward to a maximum of 10 mcg/kg/min IBW.

Usual Adult Dose for Congestive Heart Failure

Initial dose: 10 to 15 mcg/min administered by continuous IV infusion.
Maintenance dose: The dose may be titrated to 10 to 200 mcg/min.
Maximum dose: 280 mcg/min (4 mcg/kg/min).

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

The dose may be increased in increments of 0.1 to 0.3 mcg/kg/min IBW every 3 to 5 minutes.

Precautions

The risk of cyanide toxicity increases significantly when > 500 mcg/kg is administered faster than 2 mcg/kg/min IBW.

Cardiac surgery requiring cardiopulmonary bypass is associated with an increased risk of cyanide toxicity.

In pediatric patients, doses greater than 1.8 mcg/kg/min are associated with increased cyanide concentrations.

Dialysis

Data not available

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