Nitroprusside Dosage
This dosage information may not include all the information needed to use Nitroprusside safely and effectively. See additional information for Nitroprusside.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertensive Emergency
Initial dose: 0.3 mcg/kg/min IBW administered by continuous IV infusion.
Maintenance dose: The dose may be titrated upward to a maximum of 10 mcg/kg/min IBW.
Usual Adult Dose for Congestive Heart Failure
Initial dose: 10 to 15 mcg/min administered by continuous IV infusion.
Maintenance dose: The dose may be titrated to 10 to 200 mcg/min.
Maximum dose: 280 mcg/min (4 mcg/kg/min).
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Dose Adjustments
The dose may be increased in increments of 0.1 to 0.3 mcg/kg/min IBW every 3 to 5 minutes.
Precautions
The risk of cyanide toxicity increases significantly when > 500 mcg/kg is administered faster than 2 mcg/kg/min IBW.
Cardiac surgery requiring cardiopulmonary bypass is associated with an increased risk of cyanide toxicity.
In pediatric patients, doses greater than 1.8 mcg/kg/min are associated with increased cyanide concentrations.
Dialysis
Data not available
