Naproxen / Sumatriptan Dosage

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Usual Adult Dose for:

Usual Geriatric Dose for:

Additional dosage information:

Usual Adult Dose for Migraine

Dose: 1 tablet orally once (Note: The fixed combination tablet contains naproxen sodium (500 mg) and sumatriptan (85 mg).

Maximum Dose: 2 naproxen-sumatriptan tablets in 24 hours. Dosing of tablets should be at least 2 hours apart. The safety of treating an average of more than 5 migraine headaches in a 30 day period has not been established.

Naproxen-sumatriptan may be administered with or without food. Tablets should not be split, crushed, or chewed.

Usual Geriatric Dose for Migraine

Naproxen-sumatriptan is contraindicated for use in elderly patients who have abnormal hepatic function. Naproxen-sumatriptan is not recommended for use in elderly patients who have decreased renal function, higher risk for unrecognized CAD, and increases in blood pressure that may be more pronounced in the elderly.

Dose: 1 tablet orally once (Note: The fixed combination tablet contains naproxen sodium (500 mg) and sumatriptan (85 mg).

Maximum Dose: 2 naproxen-sumatriptan tablets in 24 hours. Dosing of tablets should be at least 2 hours apart. The safety of treating an average of more than 5 migraine headaches in a 30 day period has not been established.

Naproxen-sumatriptan may be administered with or without food. Tablets should not be split, crushed, or chewed.

Renal Dose Adjustments

Naproxen-sumatriptan is not recommended for use in patients with a creatinine clearance less than 30 mL/min.

Liver Dose Adjustments

Naproxen-sumatriptan is contraindicated in patients with hepatic impairment.

Precautions

Individuals may vary in response to doses of sumatriptan. The choice of the dose of sumatriptan, and of the use of a fixed dose combination such as in naproxen-sumatriptan should therefore be made on an individual basis, weighing the possible benefit of a higher dose of sumatriptan with the potential for a greater risk of adverse events. Carefully consider the potential benefits and risks of naproxen-sumatriptan and other treatment options when deciding to use naproxen-sumatriptan. Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Hemodialysis does not decrease the plasma concentration of naproxen because of the high degree of its protein binding. There are no data on the effect hemodialysis or peritoneal dialysis on the serum concentrations of sumatriptan.

Naproxen-sumatriptan is not recommended for use in patients with a creatinine clearance less than 30 mL/min.

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