Nabumetone Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Osteoarthritis

Initial: 1000 mg orally once a day at bedtime.
Maintenance: 1500 to 2000 mg orally in 1 to 2 divided doses, to a maximum daily dose of 2000 mg.

Usual Adult Dose for Rheumatoid Arthritis

Initial: 1000 mg orally once a day at bedtime.
Maintenance: 1500 to 2000 mg orally in 1 to 2 divided doses, to a maximum daily dose of 2000 mg.

Renal Dose Adjustments

CrCl greater than or equal to 30 mL/min and less than 50 mL/min: 750 mg to a maximum of 1500 mg per day
CrCl less than 30 mL/min: 500 mg to a maximum of 1000 mg per day
Not recommended in patients with advanced renal disease.

Baseline laboratory tests should be conducted at initiation of therapy and repeated within weeks. If renal function worsens, discontinuation of nabumetone may be warranted.

Liver Dose Adjustments

In patients with history of or biopsy-proven cirrhosis, the biotransformation of nabumetone to 6MNA and the further metabolism of 6MNA to inactive metabolites could be reduced. The lowest effective dose should be used for chronic treatment.

Dose Adjustments

The lowest effective dose should be used for chronic treatment. Patients weighing under 50 kg may be less likely to require dosages beyond 1000 mg.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

The active component, 6-methoxy-2-naphthylacetic acid (6MNA), is not dialyzable.

Other Comments

If no improvement is seen within 2 to 4 weeks of therapy, an alternative NSAID should be considered.

Nabumetone may be taken with or without food.

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