Mupirocin Topical Dosage

Usual Adult Dose for Skin and Structure Infection

Cream:
A small amount applied to the affected area 3 times a day for 10 days.

Ointment:
A small amount applied to the affected area 3 times a day for 7 to 14 days.

Usual Adult Dose for Nasal Carriage of Staphylococcus aureus

Divide 1/2 of the ointment from the single-use tube between the nostrils and apply twice daily for 5 days.

Usual Pediatric Dose for Skin and Structure Infection

Cream:
3 months to 16 years:
A small amount applied to the affected area 3 times a day for 10 days.

Ointment:
2 months to 16 years:
A small amount applied to the affected area 3 times a day for 7 to 14 days.

Usual Pediatric Dose for Nasal Carriage of Staphylococcus aureus

Greater than or equal to 12 years:
Divide 1/2 of the ointment from the single-use tube between the nostrils and apply twice daily for 5 days.

Renal Dose Adjustments

Mupirocin ointment is in a polyethylene glycol base, which can be absorbed by open wounds. Mupirocin should not be used in situations where large amounts of polyethylene glycol may be absorbed, especially in patients with moderate to severe renal failure.

Liver Dose Adjustments

Data not available

Precautions

Mupirocin should be discontinued if sensitization or irritation develops.

Mupirocin ointment is in a polyethylene glycol base, which can be absorbed by open wounds. Mupirocin should not be used in situations where large amounts of polyethylene glycol may be absorbed, especially in patients with moderate to severe renal failure.

Mupirocin may cause severe irritation to the eyes. Precautions are recommended to avoid any contact with the eyes.

Due to the lack of information regarding use of mupirocin with other agents applied intranasally, it is recommended that concurrent use of mupirocin nasal with other nasally applied products be avoided.

Prolonged use may result in overgrowth of nonsusceptible organisms (e.g., fungi).

Dialysis

Data not available

Other Comments

Patients not showing response in 3 to 5 days should be re-evaluated.

The safety and efficacy of applications of the nasal ointment for greater than 5 days have not been established.

See also...