Moxifloxacin Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for Bronchitis

Acute bacterial exacerbation of chronic bronchitis: 400 mg orally or IV every 24 hours for 5 days

Usual Adult Dose for Intraabdominal Infection

Complicated: 400 mg orally or IV every 24 hours for 5 to 14 days

Usual Adult Dose for Pneumonia

Community-acquired pneumonia: 400 mg orally or IV every 24 hours for 7 to 14 days

Usual Adult Dose for Sinusitis

Acute bacterial sinusitis: 400 mg orally or IV every 24 hours for 10 days

Usual Adult Dose for Skin or Soft Tissue Infection

400 mg orally or IV every 24 hours
Duration: 7 to 21 days for complicated infections; 7 days for uncomplicated infections

Usual Adult Dose for Skin and Structure Infection

400 mg orally or IV every 24 hours
Duration: 7 to 21 days for complicated infections; 7 days for uncomplicated infections

Usual Adult Dose for Inhalation Bacillus anthracis

(Not approved by FDA)

Mass casualty treatment or prophylaxis of inhalational anthrax: 400 mg orally once a day for 60 days

The Working Group on Civilian Biodefense has suggested that, based on in vitro studies, moxifloxacin could be used for postexposure prophylaxis or treatment of inhalational anthrax if ciprofloxacin and doxycycline are not available.

Usual Adult Dose for Anthrax Prophylaxis

(Not approved by FDA)

Mass casualty treatment or prophylaxis of inhalational anthrax: 400 mg orally once a day for 60 days

The Working Group on Civilian Biodefense has suggested that, based on in vitro studies, moxifloxacin could be used for postexposure prophylaxis or treatment of inhalational anthrax if ciprofloxacin and doxycycline are not available.

Usual Adult Dose for Tuberculosis - Active

(Not approved by FDA)

400 mg orally or IV once a day

This regimen has been recommended by the Centers for Disease Control and Prevention, Infectious Diseases Society of America, and American Thoracic Society.

May be given in combination with at least 3 other active drugs for treatment of multi-drug resistant TB, or when the patient is intolerant of first-line agents. AFB smear and culture should be monitored monthly.

Duration: Treatment for TB should generally continue for 18 to 24 months, or for 12 to 18 months after culture results are negative.

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

No adjustment recommended. However, the manufacturer recommends caution when administering this drug to patients with liver dysfunction.

Precautions

Consult WARNINGS section for dosing related precautions.

Dialysis

Hemodialysis and peritoneal dialysis: No adjustment recommended.

Other Comments

The manufacturer's Medication Guide should be dispensed with each new and refill prescription.

Moxifloxacin may be taken without regard to meals. Patients should be advised to drink plenty of fluids. Oral doses should be administered at least 4 hours before or 8 hours after iron-, zinc-, aluminum-, or magnesium-containing compounds (e.g., antacids, sucralfate, mineral supplements, buffered didanosine).

IV doses should be administered over at least 60 minutes.

Moxifloxacin injection is only for intravenous use and should not be refrigerated because it will precipitate. The injection contains about 787 mg of sodium in 250 mL.

Patients may be switched from IV to oral moxifloxacin when clinically indicated at the physician's discretion.

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