Methylprednisolone Dosage

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Usual Adult Dose for Allergic Rhinitis

acetate: 80 to 120 mg intramuscular only.

Usual Adult Dose for Dermatologic Lesion

acetate: 40 to 120 mg intramuscular weekly for 1 to 4 weeks.

Usual Adult Dose for Rheumatoid Arthritis

Acetate: 40 to 120 mg intramuscular weekly
Large joints: 20 to 80 mg intraarticular
Medium joints: 10 to 40 mg intraarticular
Small joints: 4 to 10 mg intraarticular

Usual Adult Dose for Adrenogenital Syndrome

Acetate: 40 mg intramuscular every 2 weeks.

Usual Adult Dose for Anti-inflammatory

4 to 48 mg/day orally.

Sodium succinate: 10 to 40 mg Intravenous over 1 to several minutes. Give subsequent doses IV or IM.

Usual Adult Dose for Shock

30 mg/kg IV repeated every 4 to 6 hours or 100 to 250 mg IV repeated every 2 to 6 hours.

Usual Adult Dose for Immunosuppression

4 to 48 mg orally per day.
2 to 2.5 mg/kg per day IV or IM, tapered slowly over 2 to 3 weeks or 250 to 1,000 mg IV once daily or on alternate days for 3 to 5 doses.

Usual Adult Dose for Asthma - Acute

Asthma exacerbations (emergency medical care or hospital doses):
Oral or IV: 40 to 80 mg/day in divided doses 1 to 2 times/day until peak expiratory flow is 70% of predicted or personal best

Short-course "burst" (acute asthma):
Oral: 40 to 60 mg/day in divided doses 1 to 2 times/day for 3 to 10 days; Note: Burst should be continued until symptoms resolve and peak expiratory flow is at least 80% of personal best; usually requires 3 to 10 days of treatment (approximately 5 days on average); longer treatment may be required
IM (acetate): 240 mg as a one-time dose (Note: This may be given in place of short-course "burst" of oral steroids in patients who are vomiting or if compliance is a problem)

Usual Adult Dose for Asthma - Maintenance

Oral: 7.5 to 60 mg daily given as a single dose in the morning or every other day as needed for asthma control

Usual Pediatric Dose for Anti-inflammatory

Sodium succinate: not less than 0.5 mg/kg/24 hours intravenous or intramuscular.

High dose therapy: 30 mg/kg intravenous over 10 to 20 minutes. May repeat every 4 to 6 hours, but not beyond 48 to 72 hours.

Usual Pediatric Dose for Asthma - Acute

Up to 11 years:
Asthma exacerbations (emergency medical care or hospital doses):
Oral or IV: 1 to 2 mg/kg/day in 2 divided doses (maximum: 60 mg/day) until peak expiratory flow is 70% of predicted or personal best.

Short-course "burst" (acute asthma):
Oral: 1 to 2 mg/kg/day in divided doses 1 to 2 times/day for 3 to 10 days; maximum dose: 60 mg/day; Note: Burst should be continued until symptoms resolve or patient achieves peak expiratory flow 80% of personal best; usually requires 3 to 10 days of treatment (approximately 5 days on average); longer treatment may be required
IM (acetate) : Note: This may be given in place of short-course "burst" of oral steroids in patients who are vomiting or if compliance is a problem:
Children up to 4 years: 7.5 mg/kg as a one-time dose; maximum dose: 240 mg
Children 5 to 11 years: 240 mg as a one-time dose.

11 years or older:
Asthma exacerbations (emergency medical care or hospital doses):
Oral or IV: 40 to 80 mg/day in divided doses 1 to 2 times/day until peak expiratory flow is 70% of predicted or personal best
Short-course "burst" (acute asthma):
Oral: 40 to 60 mg/day in divided doses 1 to 2 times/day for 3 to 10 days; Note: Burst should be continued until symptoms resolve and peak expiratory flow is at least 80% of personal best; usually requires 3 to 10 days of treatment (approximately 5 days on average); longer treatment may be required
IM (acetate): 240 mg as a one-time dose (Note: This may be given in place of short-course "burst" of oral steroids in patients who are vomiting or if compliance is a problem)

Usual Pediatric Dose for Asthma - Maintenance

Up to 11 years:
0.25 to 2 mg/kg/day given as a single dose in the morning or every other day as needed for asthma control; maximum dose: 60 mg/day.

11 years or older:
Oral: 7.5 to 60 mg orally daily given as a single dose in the morning or every other day as needed for asthma control

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Dosage adjustment should be based on severity of condition treated and response of patient.

Precautions

Methylprednisolone acetate suspension (DEPO-MEDROL)and methylprednisolone sodium succinate (Solu-Medrol) are contraindicated for use in premature infants because they contain benzyl alcohol.

Dialysis

Data not available

Other Comments

Methylprednisolone acetate is not for intravenous use.

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