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Methylnaltrexone Dosage

Medically reviewed by Drugs.com. Last updated on Jan 24, 2024.

Applies to the following strengths: 12 mg/0.6 mL; 150 mg; 8 mg/0.4 mL

Usual Adult Dose for Constipation - Drug Induced

Opioid-Induced Constipation in Patients with Chronic Non-Cancer Pain:


Comments:

Opioid-Induced Constipation in Patients with Advanced Illness:
Parenteral: Weight-based dosing: Administer subcutaneously every other day as needed, but no more frequently than 1 dose in a 24-hour period:
Less than 38 kg: 0.15 mg/kg
38 kg to less than 62 kg: 8 mg (0.4 mL)
62 kg to 114 kg: 12 mg subcutaneously (0.6 mL)
More than 114 kg: 0.15 mg/kg subcutaneously

Comments: To determine injection volume for patients whose weight is less than 38 kg or more than 114 kg: multiply patient weight (kg) by 0.0075 and round up to the nearest 0.1 mL

Uses:

Renal Dose Adjustments

Moderate to severe renal impairment (CrCl less than 60 mL/min):

Chronic Non-Cancer Pain:


Advanced Illness:
Parenteral: weight-based dosing:
Less than 38 kg: 0.075 mg/kg subcutaneously every other day
38 to less than 62 kg: 4 mg subcutaneously every other day
62 to 114 kg: 6 mg subcutaneously every other day
Greater than 114 kg: 0.075 mg/kg subcutaneously every other day

Comments: To determine injection volume for patients whose weight is less than 38 kg or more than 114 kg: multiply patient weight (kg) by 0.0075 and round up to the nearest 0.1 mL

Liver Dose Adjustments

Moderate to severe hepatic impairment (Child-Pugh Class B or C):


Severe hepatic impairment: Chronic Non-Cancer Pain or Advanced illness:
Less than 38 kg: 0.075 mg/kg subcutaneously every other day
38 to less than 62 kg: 4 mg subcutaneously every other day
62 to 114 kg: 6 mg subcutaneously every other day
Greater than 114 kg: 0.075 mg/kg subcutaneously every other day

Comments: To determine injection volume for patients whose weight is less than 38 kg or more than 114 kg: multiply patient weight (kg) by 0.0075 and round up to the nearest 0.1 mL

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Oral tablets:

Parenteral:

Storage requirements:

Reconstitution/preparation techniques: See product information.

General:

Monitoring:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.