Medication Guide App

Methylnaltrexone Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Constipation - Chronic

Less than 38 kg: 0.15 mg/kg subcutaneously every other day as needed
38 to less than 62 kg: 8 mg subcutaneously every other day as needed
62 to 114 kg: 12 mg subcutaneously every other day as needed
More than 114 kg: 0.15 mg/kg subcutaneously every other day as needed

The usual schedule is one dose every other day, as needed, but no more frequently than one dose in a 24-hour period.

Renal Dose Adjustments

CrCl 30 to 80 mL/min: No adjustment recommended

CrCl less than 30 mL/min:
Less than 38 kg: 0.075 mg/kg subcutaneously every other day as needed
38 to less than 62 kg: 4 mg subcutaneously every other day as needed
62 to 114 kg: 6 mg subcutaneously every other day as needed
More than 114 kg: 0.075 mg/kg subcutaneously every other day as needed

Liver Dose Adjustments

Mild to moderate hepatic impairment: No adjustment recommended
Severe hepatic impairment: Data not available

Precautions

Methylnaltrexone is contraindicated in patients with suspected or known mechanical gastrointestinal obstruction.

If severe or persistent diarrhea is observed during treatment, patients should be advised to discontinue therapy with methylnaltrexone and consult their physician.

Methylnaltrexone has not been studied in patients with peritoneal catheters.

The safety and efficacy of methylnaltrexone have not been established in pediatric patients.

Dialysis

Data not available

Other Comments

If patient weight is less than 38 kg, multiply the weight in kg by 0.0075 and round up the volume to the nearest 0.1 mL.
If patient weight is 38 kg to less than 62 kg, give 0.4 mL.
If patient weight is 62 kg to less than 115 kg, give 0.6 mL.
If patient weight is 115 kg or greater, multiply the weight in kg by 0.0075 and round up the volume to the nearest 0.1 mL.

Use of methylnaltrexone beyond four months has not been evaluated.

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