This dosage information may not include all the information needed to use Methyldopa safely and effectively. See additional information for Methyldopa.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Initial dose: 250 mg orally 2-3 times a day or 250 to 500 mg IV over 30 to 60 minutes every 6 hours, up to a maximum of 3 g/day.
Maintenance dose: 500 mg to 2 g orally divided in 2 to 4 doses, up to a maximum of 3 g/day.
Usual Adult Dose for Hypertensive Emergency
250 to 500 mg IV over 30 to 60 minutes every 6 hours up to a maximum of 1 g every 6 hours or 4 g/day. Switch to the oral route at the same dosage once blood pressure is under control.
Renal Dose Adjustments
CrCl < 15 mL/min: The dosage interval should be every 12 to 24 hours.
CrCl 15-50 mL/min: The dosage interval should be every 8 to 12 hours.
Liver Dose Adjustments
Methyldopa is contraindicated in patients with active hepatic disease, such as acute hepatitis and active cirrhosis.
The daily dosage may be increased in intervals of not less than 2 days. Geriatric patients may require lower doses to minimize the risk of syncope.
Initiate treatment with lower doses if given concurrently with other antihypertensive agents.
Following intravenous administration, the antihypertensive effect has an onset of 4 to 6 hours and a duration of 10 to 16 hours. Due to the slow onset of action, alternative therapy maybe indicated in serious situations.
Methyldopa is slightly dialyzable (5%-20%).