Mesnex Dosage
Generic name: mesna
Dosage form: tablet, injection
This dosage information does not include all the information needed to use Mesnex safely and effectively. See full prescribing information for Mesnex.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
For the prophylaxis of ifosfamide induced hemorrhagic cystitis, MESNEX may be given on a fractionated dosing schedule of three bolus intravenous injections or a single bolus injection followed by two oral administrations of MESNEX Tablets as outlined below.
Intravenous Schedule
MESNEX is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage (w/w) at the time of ifosfamide administration and 4 and 8 hours after each dose of ifosfamide. The total daily dose of mesna is 60% of the ifosfamide dose.
The recommended dosing schedule is outlined below:
| 0 Hours | 4 Hours | 8 Hours | |
| Ifosfamide | 1.2 g/m2 | – | – |
| MESNEX | 240 mg/m2 | 240 mg/m2 | 240 mg/m2 |
Intravenous and Oral Dosing
MESNEX Injection is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage (w/w) at the time of ifosfamide administration. MESNEX Tablets are given orally in a dosage equal to 40% of the ifosfamide dose 2 and 6 hours after each dose of ifosfamide. The total daily dose of mesna is 100% of the ifosfamide dose.
The recommended dosing schedule is outlined below:
| 0 Hours | 2 Hours | 6 Hours | |
| Ifosfamide | 1.2 g/m2 | – | – |
| MESNEX Injection | 240 mg/m2 | – | – |
| MESNEX Tablets | – | 480 mg/m2 | 480 mg/m2 |
Patients who vomit within two hours of taking oral mesna should repeat the dose or receive intravenous mesna. The efficacy and safety of this ratio of IV and PO mesna has not been established as being effective for daily doses of IFEX higher than 2.0 g/m2.
The dosing schedule should be repeated on each day that ifosfamide is administered. When the dosage of ifosfamide is adjusted (either increased or decreased), the ratio of MESNEX to IFEX should be maintained.
Preparation of Intravenous Solutions/Stability
The MESNEXmultidose vials may be stored and used for up to 8 days.
For IV administration the drug can be diluted by adding the MESNEX Injection solution to any of the following fluids obtaining final concentrations of 20 mg mesna/mL:
- 5% Dextrose Injection, USP
- 5% Dextrose and 0.2% Sodium Chloride Injection, USP
- 5% Dextrose and 0.33% Sodium Chloride Injection, USP
- 5% Dextrose and 0.45% Sodium Chloride Injection, USP
- 0.92% Sodium Chloride Injection, USP
- Lactated Ringer’s Injection, USP
For example:
One mL of MESNEX Injection multidose vial 100 mg/mL may be added to 4 mL of any of the solutions listed above to create a final concentration of 20 mg mesna/mL.
Diluted solutions are chemically and physically stable for 24 hours at 25°C (77°F).
Mesna is not compatible with cisplatin or carboplatin.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration.
