Meperidine Dosage

This dosage information may not include all the information needed to use Meperidine safely and effectively. See additional information for Meperidine.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Geriatric Dose for:

Additional dosage information:

Usual Adult Dose for Pain

Oral: 50 to 100 mg every 4 hours as needed.
IV,IM,subcutaneously: 25 to 100 mg every 4 hours as needed.
Continuous IV: 15 to 35 mg/hr.

Usual Adult Dose for Light Sedation

Premedication for Anesthesia:
50 to 100 mg IM or subcutaneously 30 to 90 minutes prior to anesthesia.

Usual Geriatric Dose for Pain

Oral: 50 mg every 4 hours as needed.
IM: 25 mg every 4 hours as needed.

Renal Dose Adjustments

Use with caution and reduce dose. Accumulation of meperidine and its active metabolite (normeperidine) may occur.

CrCl less than 10 mL/min: The dose should be given at 50% of the normal dose.

CrCl 10 to 50 mL/min: The dose should be given at 75% of the normal dose.

Liver Dose Adjustments

Use with caution and reduce dose. Accumulation of meperidine and its active metabolite (normeperidine) may occur.

Dose Adjustments

Doses should be titrated to appropriate analgesic effect. When changing route of administration, it should be noted that oral doses are about half as effective as parenteral doses.

Factors such as age, disease state, concomitant drug therapy, and tolerance to narcotics can have variable but important effects on dose and response.

Dialysis

Data not available

Other Comments

The onset of action occurs: oral - 15 min., IM and subcutaneously - 10 min, IV - 2-10 min.
The peak occurs: oral, IM, and subcutaneously - 1 hour, IV - 30-60 min. .

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