Medroxyprogesterone Dosage

Usual Adult Dose for Endometriosis

104 mg subcutaneously once every three months. The first dose should only be given within the first 5 days of a normal menstrual period, within 5 days postpartum if the patient is not breast feeding, or at 6 weeks postpartum if the patient is breast feeding. If the period between injections is > 14 weeks, pregnancy should be ruled out prior to administering.

Usual Adult Dose for Endometrial Hyperplasia - Prophylaxis

5 to 10 mg orally once a day, as a adjunct to estrogen replacement therapy, beginning on day one 1 or day 16 of each cycle and continuing for 12 to 14 consecutive days per month.

-or-

2.5 mg orally once a day continuously during estrogen replacement therapy.

Usual Adult Dose for Contraception

150 mg intramuscularly or 104 mg subcutaneously every 3 months. The first dose should only be given within the first 5 days of a normal menstrual period, within 5 days postpartum if the patient is not breast feeding, or at 6 weeks postpartum if the patient is breast feeding. If the period between injections is > 14 weeks, pregnancy should be ruled out prior to administering.

Usual Adult Dose for Abnormal Uterine Bleeding

5 to 10 mg orally once a day, beginning on the 16th day of the cycle and continue for 10 days or begin on the 21st day of the cycle and continue for 5 days. Withdrawal bleeding usually occurs within 3 to 7 days after the last dose.

Usual Adult Dose for Amenorrhea

5 to 10 mg orally once a day beginning at any time and continuing for 5 to 10 days. Withdrawal bleeding usually occurs within 3 to 7 days after the last dose.

Usual Adult Dose for Renal Cell Carcinoma

400 to 1000 mg IM once a week. May reduce to as little as 400 mg IM once a month. The frequency of administration may be reduced if improvement or stabilization occurs, usually within a few weeks to months.

Usual Adult Dose for Endometrial Carcinoma

400 to 1000 mg IM once a week. May reduce to as little as 400 mg IM once a month. The frequency of administration may be reduced if improvement or stabilization occurs, usually within a few weeks to months.

Usual Pediatric Dose for Abnormal Uterine Bleeding

>13 years:
5 to 10 mg orally once a day, beginning on the 16th day of the cycle and continue for 10 days or begin on the 21st day of the cycle and continue for 5 days. Withdrawal bleeding usually occurs within 3 to 7 days after the last dose.

Usual Pediatric Dose for Amenorrhea

> 13 years:
5 to 10 mg orally once a day beginning at any time and continuing for 5 to 10 days. Withdrawal bleeding usually occurs within 3 to 7 days after the last dose.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Medroxyprogesterone is contraindicated in patients with significant liver disease.

Precautions

The subcutaneous and intramuscular formulations are NOT interchangeable.

Dialysis

Data not available

See also...