Meclofenamate Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Pain

Mild to moderate pain:
Initial dose: 50 mg orally every 4 to 6 hours
Maintenance dose: 50 mg orally every 4 to 6 hours or 100 mg orally every 6 hours
Maximum dose: 400 mg orally per day

Usual Adult Dose for Dysmenorrhea

Primary dysmenorrhea and excessive menstrual blood loss:
100 mg orally 3 times a day, for up to 6 days, starting at the onset of menstrual flow
Maximum dose: 400 mg orally per day

Usual Adult Dose for Osteoarthritis

200 to 400 mg orally per day, administered in 3 to 4 equal doses
Maximum dose: 400 mg orally per day

Usual Adult Dose for Rheumatoid Arthritis

200 to 400 mg orally per day, administered in 3 to 4 equal doses
Maximum dose: 400 mg orally per day

Renal Dose Adjustments

The manufacturer recommends a lower daily dose in patients with significant renal dysfunction to avoid drug accumulation.

Liver Dose Adjustments

No adjustment recommended

Dose Adjustments

After a satisfactory response has been achieved, the dosage should be adjusted as required. A lower dosage may suffice for long-term administration.

A lower starting dose and careful follow-up is recommended in elderly patients due to adverse effects that are more common in this population.

Precautions

If gastrointestinal upset occurs, meclofenamate may be administered with meals or milk.

Safety and effectiveness have not been established in pediatric patients below the age of 14 years.

Dialysis

No adjustment recommended

Other Comments

Although improvement may be seen in some patients in a few days, 2 to 3 weeks of treatment may be required to obtain the optimum therapeutic benefit.

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