Lurasidone Dosage

This dosage information may not include all the information needed to use Lurasidone safely and effectively. See additional information for Lurasidone.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Schizophrenia

Initial dose: 40 mg orally once daily. Initial dose titration is not required.
Maximum dose: 160 mg once daily.

Renal Dose Adjustments

Dose adjustment is recommended in moderate renal impairment (CrCl 30 to less than 50 mL/min) and severe renal impairment (CrCl less than 30 mL/min):
Initial recommended starting dose: 20 mg orally daily
Maximum recommended dose: 80 mg orally daily

Liver Dose Adjustments

Moderate hepatic impairment (Child Pugh Score 7 to 9):
Initial dose: 20 mg orally daily
Maximum dose: 80 mg orally daily

Severe hepatic impairment (Child Pugh Score 10 to 15):
Initial dose: 20 mg orally daily
Maximum dose: 40 mg orally daily

Dose Adjustments

When coadministration of lurasidone with a moderate CYP450 3A4 inhibitor such as diltiazem is considered, the dose should not exceed 80 mg/day. Lurasidone should not be used in combination on with a strong CYP450 3A4 inhibitor (e.g., ketoconazole).

Lurasidone should not be used in combination with a strong CYP450 3A4 inducer (e.g., rifampin).

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available.

Other Comments

Lurasidone should be taken with food (at least 350 calories).

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