Lurasidone Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Schizophrenia

Initial dose: 40 mg orally once daily. Initial dose titration is not required.
Maximum dose: 160 mg once daily.

Comments: Should be taken with food (at least 350 calories). Administration with food substantially increases drug absorption.

Approved indication: Schizophrenia

Usual Adult Dose for Bipolar Disorder

Initial dose: 20 mg orally once daily as monotherapy or as adjunctive therapy with lithium or valproate. Initial dose titration is not required.
Maximum dose: 120 mg once daily as monotherapy or as adjunctive therapy with lithium or valproate.

Comments: Should be taken with food (at least 350 calories). Administration with food substantially increases drug absorption.

Approved indication: Depressive episodes associated with Bipolar I Disorder

Renal Dose Adjustments

Dose adjustment is recommended in moderate renal impairment (CrCl 30 to less than 50 mL/min) and severe renal impairment (CrCl less than 30 mL/min):
Initial recommended starting dose: 20 mg orally daily
Maximum recommended dose: 80 mg orally daily

Liver Dose Adjustments

Moderate hepatic impairment (Child Pugh Score 7 to 9):
Initial dose: 20 mg orally daily
Maximum dose: 80 mg orally daily

Severe hepatic impairment (Child Pugh Score 10 to 15):
Initial dose: 20 mg orally daily
Maximum dose: 40 mg orally daily

Dose Adjustments

When coadministration of lurasidone with a moderate CYP450 3A4 inhibitor such as diltiazem is considered, the dose should not exceed 80 mg/day. Lurasidone should not be used in combination on with a strong CYP450 3A4 inhibitor (e.g., ketoconazole).

Lurasidone should not be used in combination with a strong CYP450 3A4 inducer (e.g., rifampin).

Dialysis

Data not available.

Other Comments

Lurasidone should be taken with food (at least 350 calories).

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