This dosage information may not include all the information needed to use Lurasidone safely and effectively. See additional information for Lurasidone.
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Schizophrenia
40 mg orally once daily. Initial dose titration is not required. The maximum recommended dose is 80 mg once daily.
Renal Dose Adjustments
Dose adjustment is recommended in moderate and severe renal impairment (Clcr equal to or greater than 10 mL/min to less than 50 mL/min) patients. The dose in these patients should not exceed 40 mg/day.
Liver Dose Adjustments
Dose adjustment is recommended in moderate and severe hepatic impairment (Child-Pugh Class B and C) patients. The dose in these patients should not exceed 40 mg/day.
When coadministration of lurasidone with a moderate CYP450 3A4 inhibitor such as diltiazem is considered, the dose should not exceed 40 mg/day. Lurasidone should not be used in combination on with a strong CYP450 3A4 inhibitor (e.g., ketoconazole).
Lurasidone should not be used in combination with a strong CYP450 3A4 inducer (e.g., rifampin).
Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
Data not available.