Loteprednol / Tobramycin Ophthalmic Dosage

Medically reviewed by Drugs.com. Last updated on Nov 20, 2023.

Usual Adult Dose for Uveitis

Apply 1 or 2 drops into the conjunctival sac of the affected eye(s) every 4 to 6 hours; during the initial 24 to 48 hours, may increase frequency to every 1 to 2 hours

Comments:

• The frequency should be gradually decreased as warranted by improvement of clinical signs.
• Care should be taken as to not discontinue therapy prematurely.
• A maximum of 20 mL should be prescribed initially and not refilled without further evaluation.

Use: For the treatment of steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or risk of bacterial ocular infection exists; the anti-infective component of this drug is active against the following common bacterial eye pathogens: Staphylococcus aureus, S epidermidis (coagulase positive and negative), some Group A beta-hemolytic and some nonhemolytic streptococci, and some Streptococcus pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, most Proteus vulgaris strains, Haemophilus influenzae, H aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus, Klebsiella pneumoniae, and some Neisseria species

Usual Adult Dose for Iritis

Apply 1 or 2 drops into the conjunctival sac of the affected eye(s) every 4 to 6 hours; during the initial 24 to 48 hours, may increase frequency to every 1 to 2 hours

Comments:

• The frequency should be gradually decreased as warranted by improvement of clinical signs.
• Care should be taken as to not discontinue therapy prematurely.
• A maximum of 20 mL should be prescribed initially and not refilled without further evaluation.

Use: For the treatment of steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or risk of bacterial ocular infection exists; the anti-infective component of this drug is active against the following common bacterial eye pathogens: Staphylococcus aureus, S epidermidis (coagulase positive and negative), some Group A beta-hemolytic and some nonhemolytic streptococci, and some Streptococcus pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, most Proteus vulgaris strains, Haemophilus influenzae, H aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus, Klebsiella pneumoniae, and some Neisseria species

Usual Adult Dose for Ocular Infection

Apply 1 or 2 drops into the conjunctival sac of the affected eye(s) every 4 to 6 hours; during the initial 24 to 48 hours, may increase frequency to every 1 to 2 hours

Comments:

• The frequency should be gradually decreased as warranted by improvement of clinical signs.
• Care should be taken as to not discontinue therapy prematurely.
• A maximum of 20 mL should be prescribed initially and not refilled without further evaluation.

Use: For the treatment of steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or risk of bacterial ocular infection exists; the anti-infective component of this drug is active against the following common bacterial eye pathogens: Staphylococcus aureus, S epidermidis (coagulase positive and negative), some Group A beta-hemolytic and some nonhemolytic streptococci, and some Streptococcus pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, most Proteus vulgaris strains, Haemophilus influenzae, H aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus, Klebsiella pneumoniae, and some Neisseria species

Usual Adult Dose for Allergic Conjunctivitis

Apply 1 or 2 drops into the conjunctival sac of the affected eye(s) every 4 to 6 hours; during the initial 24 to 48 hours, may increase frequency to every 1 to 2 hours

Comments:

• The frequency should be gradually decreased as warranted by improvement of clinical signs.
• Care should be taken as to not discontinue therapy prematurely.
• A maximum of 20 mL should be prescribed initially and not refilled without further evaluation.

Use: For the treatment of steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or risk of bacterial ocular infection exists; the anti-infective component of this drug is active against the following common bacterial eye pathogens: Staphylococcus aureus, S epidermidis (coagulase positive and negative), some Group A beta-hemolytic and some nonhemolytic streptococci, and some Streptococcus pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, most Proteus vulgaris strains, Haemophilus influenzae, H aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus, Klebsiella pneumoniae, and some Neisseria species

Usual Adult Dose for Bacterial Conjunctivitis

Apply 1 or 2 drops into the conjunctival sac of the affected eye(s) every 4 to 6 hours; during the initial 24 to 48 hours, may increase frequency to every 1 to 2 hours

Comments:

• The frequency should be gradually decreased as warranted by improvement of clinical signs.
• Care should be taken as to not discontinue therapy prematurely.
• A maximum of 20 mL should be prescribed initially and not refilled without further evaluation.

Use: For the treatment of steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or risk of bacterial ocular infection exists; the anti-infective component of this drug is active against the following common bacterial eye pathogens: Staphylococcus aureus, S epidermidis (coagulase positive and negative), some Group A beta-hemolytic and some nonhemolytic streptococci, and some Streptococcus pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, most Proteus vulgaris strains, Haemophilus influenzae, H aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus, Klebsiella pneumoniae, and some Neisseria species

Usual Adult Dose for Keratitis

Apply 1 or 2 drops into the conjunctival sac of the affected eye(s) every 4 to 6 hours; during the initial 24 to 48 hours, may increase frequency to every 1 to 2 hours

Comments:

• The frequency should be gradually decreased as warranted by improvement of clinical signs.
• Care should be taken as to not discontinue therapy prematurely.
• A maximum of 20 mL should be prescribed initially and not refilled without further evaluation.

Use: For the treatment of steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or risk of bacterial ocular infection exists; the anti-infective component of this drug is active against the following common bacterial eye pathogens: Staphylococcus aureus, S epidermidis (coagulase positive and negative), some Group A beta-hemolytic and some nonhemolytic streptococci, and some Streptococcus pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, most Proteus vulgaris strains, Haemophilus influenzae, H aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus, Klebsiella pneumoniae, and some Neisseria species

Usual Adult Dose for Cyclitis

Apply 1 or 2 drops into the conjunctival sac of the affected eye(s) every 4 to 6 hours; during the initial 24 to 48 hours, may increase frequency to every 1 to 2 hours

Comments:

• The frequency should be gradually decreased as warranted by improvement of clinical signs.
• Care should be taken as to not discontinue therapy prematurely.
• A maximum of 20 mL should be prescribed initially and not refilled without further evaluation.

Use: For the treatment of steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or risk of bacterial ocular infection exists; the anti-infective component of this drug is active against the following common bacterial eye pathogens: Staphylococcus aureus, S epidermidis (coagulase positive and negative), some Group A beta-hemolytic and some nonhemolytic streptococci, and some Streptococcus pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, most Proteus vulgaris strains, Haemophilus influenzae, H aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus, Klebsiella pneumoniae, and some Neisseria species

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• For ophthalmic use only.
• Shake well before use.

Storage requirements:

• Store upright.
• Protect from freezing.

Monitoring:

• Ocular: Routinely measure intraocular pressure if this drug is used for 10 days or longer.

Patient advice:

• Avoid allowing the tip of the dropper to touch any surface as this may contaminate the suspension.
• If pain develops, redness, itching, or inflammation becomes aggravated, consult a physician.
• Avoid wearing soft contact lenses when using this drug.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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