Lindane Topical Dosage

This dosage information may not include all the information needed to use Lindane Topical safely and effectively. See additional information for Lindane Topical.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Scabies

1% lotion applied to the skin (neck to toes) and left on for 8 to 12 hours. Afterwards patient should bathe thoroughly.

Safer agents should be tried first (i.e., crotamiton, permethrin, malathion).

Usual Adult Dose for Lice

15 to 30 mL of 1% shampoo applied for 4 to 5 minutes one time. Up to 60 mL may be necessary for long, dense hair. Apply to dry hair and rinse hair well when complete. Combing with a fine tooth comb helps remove nits.

Safer agents should be tried first (i.e., pyrethrum with piperonyl butoxide, permethrin).

Usual Pediatric Dose for Scabies

<1 month: Contraindicated.

>1 month, <50 kg: Extreme caution is recommended due to the risk of adverse events.

>1 month, >50 kg: Apply a thin layer of 1% lotion or liquid and massage it on skin from head to toes. Wash off 6 to 8 hours after application.

Safer agents should be tried first (i.e., crotamiton, permethrin, malathion).

Usual Pediatric Dose for Lice

<1 month: Contraindicated.

>1 month, <50 kg: Extreme caution is recommended due to the risk of adverse events.

>1 month, >50 kg: 15 to 30 mL of 1% shampoo applied for 4 to 5 minutes one time. Up to 60 mL may be necessary for long, dense hair. Apply to dry hair and rinse hair well when complete. Combing with a fine tooth comb helps remove nits.

Safer agents should be tried first (i.e., pyrethrum with piperonyl butoxide, permethrin).

Dose Adjustments

Repeat treatment should only be used for persistent infection or reinfection verified by identification of viable mites. At least 1 week should lapse before retreatment.

Precautions

Lindane is considered a second-line treatment for pediculosis and scabies in patients who cannot tolerate or have failed to respond to safer treatments.

Repeated use is not recommended.

Application following a bath to hydrated skin increases systemic absorption.

Lindane lotion should not be left on the skin for > 12 hours.

Contact with eyes and face should be avoided.

Lindane is contraindicated in patients with uncontrolled seizure disorders, premature infants, and patients with open wounds, cuts, sores, crusted (Norwegian) scabies or other dermatologic conditions (psoriasis, atopic dermatitis) that may increase systemic absorption.

Neurotoxicity has been reported with prolonged and repeated use, and onetime use. Due to the risk of severe neurologic toxicity (seizures and deaths), caution is recommended in infants, children, elderly patients, patients weighing less than 50 kg (110 lbs), patients with increased risk of seizures (e.g., HIV infection, head trauma, prior seizure, CNS tumor, severe hepatic cirrhosis, excessive alcohol use, abrupt withdrawal of alcohol, or concomitant medication that lower the seizure threshold).

No more than 2 ounces of the lotion or shampoo may be dispensed to each patient. Patients should be given written and verbal instructions regarding the proper use of lindane. The manufacturer's medication guide is required by law to be dispensed with lindane.

Caregivers should wear less permeable gloves when applying lindane (nitrile, latex with neoprene, sheer vinyl) and thoroughly wash their hands after application. Natural latex is more permeable to lindane and should be avoided. Contact should be avoided by pregnant individuals.

Application of oil treatments, oil-based hair dressings, conditioners, lotions, or creams before and after lindane application should be avoided because they may increase absorption and the risk of neurotoxicity.

Other Comments

Pruritus may persist for several weeks following adequate treatment, but is not an indication for retreatment.

Patients should be instructed to apply lindane lotion to cool, dry skin.

Treatment of close contacts should be considered to avoid reinfection. All clothing and bedding should be washed in hot water and dried in a hot dryer or dry cleaned.

In cases of pediculosis pubis, sexual contacts should be treated concurrently.

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