Lexiva Dosage
Generic name: fosamprenavir calcium
Dosage form: tablet, film coated: oral suspension
This dosage information does not include all the information needed to use Lexiva safely and effectively. See full prescribing information for Lexiva.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
LEXIVA Tablets may be taken with or without food.
Adults should take LEXIVA Oral Suspension without food. Pediatric patients should take LEXIVA Oral Suspension with food [see Clinical Pharmacology (12.3)]. If emesis occurs within 30 minutes after dosing, re-dosing of LEXIVA Oral Suspension should occur.
Higher-than-approved dose combinations of LEXIVA plus ritonavir are not recommended due to an increased risk of transaminase elevations [see Overdosage (10)].
When LEXIVA is used in combination with ritonavir, prescribers should consult the full prescribing information for ritonavir.
Adults
Therapy-Naive Adults
- LEXIVA 1,400 mg twice daily (without ritonavir).
- LEXIVA 1,400 mg once daily plus ritonavir 200 mg once daily.
- LEXIVA 1,400 mg once daily plus ritonavir 100 mg once daily.
Dosing of LEXIVA 1,400 mg once daily plus ritonavir 100 mg once daily is supported by pharmacokinetic data [see Clinical Pharmacology (12.3)].
- LEXIVA 700 mg twice daily plus ritonavir 100 mg twice daily.
- Dosing of LEXIVA 700 mg twice daily plus 100 mg ritonavir twice daily is supported by pharmacokinetic and safety data [see Clinical Pharmacology (12.3)].
Protease Inhibitor-Experienced Adults
- LEXIVA 700 mg twice daily plus ritonavir 100 mg twice daily
Pediatric Patients (Aged 2 to 18 Years)
The recommended dosage of LEXIVA in patients aged greater than or equal to 2 years should be calculated based on body weight (kg) and should not exceed the recommended adult dose. The data are insufficient to recommend: (1) once-daily dosing of LEXIVA alone or in combination with ritonavir, and (2) any dosing of LEXIVA in therapy-experienced patients aged 2 to 5 years.
Therapy-Naive Aged 2 to 5 Years
- LEXIVA Oral Suspension 30 mg/kg twice daily, not to exceed the adult dose of LEXIVA 1,400 mg twice daily.
Therapy-Naive Aged Greater Than or Equal to 6 Years
- Either LEXIVA Oral Suspension 30 mg/kg twice daily not to exceed the adult dose of LEXIVA 1,400 mg twice daily or LEXIVA Oral Suspension 18 mg/kg plus ritonavir 3 mg/kg twice daily not to exceed the adult dose of LEXIVA 700 mg plus ritonavir 100 mg twice daily.
Therapy-Experienced Aged Greater Than or Equal to 6 Years
- LEXIVA Oral Suspension 18 mg/kg plus ritonavir 3 mg/kg administered twice daily not to exceed the adult dose of LEXIVA 700 mg twice daily plus ritonavir 100 mg twice daily.
Other Dosing Considerations
- When administered without ritonavir, the adult regimen of LEXIVA Tablets 1,400 mg twice daily may be used for pediatric patients weighing at least 47 kg.
- When administered in combination with ritonavir, LEXIVA Tablets may be used for pediatric patients weighing at least 39 kg; ritonavir capsules may be used for pediatric patients weighing at least 33 kg.
Patients With Hepatic Impairment
See Clinical Pharmacology (12.3).
Mild Hepatic Impairment (Child-Pugh Score Ranging From 5 to 6): LEXIVA should be used with caution at a reduced dosage of 700 mg twice daily without ritonavir (therapy-naive) or 700 mg twice daily plus ritonavir 100 mg once daily (therapy-naive or protease inhibitor-experienced).
Moderate Hepatic Impairment (Child-Pugh Score Ranging From 7 to 9): LEXIVA should be used with caution at a reduced dosage of 700 mg twice daily without ritonavir (therapy-naive), or 450 mg twice daily plus ritonavir 100 mg once daily (therapy-naive or protease inhibitor-experienced).
Severe Hepatic Impairment (Child-Pugh Score Ranging From 10 to 15): LEXIVA should be used with caution at a reduced dosage of 350 mg twice daily without ritonavir (therapy-naive) or 300 mg twice daily plus ritonavir 100 mg once daily (therapy-naive or protease inhibitor-experienced).
