Letrozole Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Breast Cancer

For use as first-line treatment of postmenopausal women with hormone receptor positive or hormone receptor unknown locally advanced or metastatic breast cancer. Letrozole is also indicated for the treatment of advanced breast cancer in postmenopausal women with disease progression following antiestrogen therapy: 2.5 mg tablet orally administered once a day without regard to meals.

In patients with advanced disease, letrozole therapy should continue until tumor progression is evident.

Usual Adult Dose for Breast Cancer - Adjuvant

For use as extended adjuvant treatment of early breast cancer in postmenopausal women who have received 5 years of adjuvant tamoxifen therapy: 2.5 mg tablet orally administered once a day without regard to meals.

The optimal duration of treatment with letrozole is not known. Treatment should be discontinued if there is a tumor relapse.

Renal Dose Adjustments

No dosage requirement is required for patients with a creatinine clearance >= 10 mL/min.

Liver Dose Adjustments

No dosage adjustment is required for patients with mild to moderate hepatic impairment. Patients with severe impairment should be dosed with caution.

Dose Adjustments

No dosage adjustment is required in elderly patients.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

Patients treated with letrozole do not require glucocorticoid or mineralocorticoid replacement therapy.

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