Lansoprazole Dosage

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Usual Adult Dose for Erosive Esophagitis

Initial dose: 30 mg orally once a day for up to 8 weeks. Alternatively, if the patient is unable to use oral route the dose may be given as an IV infusion of 30 mg per day administered over 30 minutes for up to 7 days.

Maintenance dose: 15 mg orally once a day.

Usual Adult Dose for Duodenal Ulcer

15 mg orally once a day 30 minutes before eating. Therapy should be continued for up to 4 weeks.

Usual Adult Dose for Gastroesophageal Reflux Disease

15 mg orally once a day. Therapy should be continued for up to 8 weeks.

Usual Adult Dose for Gastric Ulcer

30 mg orally once a day 30 minutes before eating. Therapy should be continued for 4 to 8 weeks.

Usual Adult Dose for Multiple Endocrine Adenomas

60 mg orally once a day. Doses up to 90 mg orally 2 times a day have been used. The manufacturer reports that some patients have been treated continuously for as long as four years.

Usual Adult Dose for Systemic Mastocytosis

60 mg orally once a day. Doses up to 90 mg orally 2 times a day have been used. The manufacturer reports that some patients have been treated continuously for as long as four years.

Usual Adult Dose for Zollinger-Ellison Syndrome

60 mg orally once a day. Doses up to 90 mg orally 2 times a day have been used. The manufacturer reports that some patients have been treated continuously for as long as four years.

Usual Adult Dose for Helicobacter pylori Infection

Triple therapy: lansoprazole 30 mg is combined with 1 g of amoxicillin and 500 mg of clarithromycin given orally every 12 hours for 10 or 14 days. Most investigators recommend treatment with at least two antimicrobial agents in order to achieve eradication. Monotherapy with lansoprazole is ineffective and should be avoided.

Dual therapy: lansoprazole 30 mg is combined with 1 gram of amoxicillin given orally every 8 hours for 14 days. Refer to the monograph for amoxicillin and/or clarithromycin for dosing information specific to elderly or renally-impaired patients.

Usual Adult Dose for Duodenal Ulcer Prophylaxis

15 mg orally once a day 30 minutes before eating. Studies evaluating maintenance therapy for duodenal ulcers have not extended beyond 12 months.

Usual Adult Dose for NSAID-Induced Gastric Ulcer

30 mg orally once a day for 8 weeks.

Usual Adult Dose for NSAID-Induced Ulcer Prophylaxis

15 mg orally once a day for up to 12 weeks.

Usual Pediatric Dose for Aspiration Pneumonia

Study (n=120)
Greater than 3 to 11 years: 30 mg at 9 p.m. the night before surgery, and 30 mg at 5:30 a.m. the day of surgery.

Usual Pediatric Dose for Gastroesophageal Reflux Disease

Short term treatment of GERD (up to 12 weeks):
1 to 11 years:
Less than or equal to 30 kg = 15 mg once daily
Greater than 30 kg = 30 mg once daily

12 to 17 years: 15 mg once daily for up to 8 weeks

Usual Pediatric Dose for Erosive Esophagitis

Short term treatment (up to 12 weeks):
1 to 11 years:
Less than or equal to 30 kg = 15 mg once daily
Greater than 30 kg = 30 mg once daily, up to 30 mg twice daily.

Short term treatment (up to 8 weeks):
12 to 17 years: 30 mg once daily
An additional 8 weeks may be tried in those patients who fail to respond or for a recurrence.
Maintenance: 15 mg once daily

Renal Dose Adjustments

No adjustments recommended

Liver Dose Adjustments

Erosive Esophagitis and Gastric Ulcer: 15 mg orally once a day.
Zollinger-Ellison Syndrome, Multiple Endocrine Adenomas, and Systemic Mastocytosis: 30 mg orally once a day.
Helicobacter Pylori Infection: 15 mg orally twice a day.

Dose Adjustments

Daily doses above 120 mg should be administered in 2 equally divided doses.

Precautions

If lansoprazole is used in combination with other drugs in dual, triple, or quadruple therapy, the clinician is advised to refer to specific warning, precaution, and contraindication information for each drug.

Lansoprazole is not effective in patients with symptomatic GERD age 1 month to less than 1 year of age.

Dialysis

Lansoprazole is not dialyzable. No adjustment recommended.

Other Comments

Lansoprazole should be administered before eating.

Lansoprazole delayed-release capsules may be opened and sprinkled onto a tablespoon of applesauce, pudding, cottage cheese, yogurt, or strained pears and swallowed immediately. Do not chew or crush granules. Alternatively, it may also be emptied into a small volume (60 mL) of either apple juice, orange juice or tomato juice and swallowed immediately. Rinse glass with more juice and swallow immediately.

For patients fed through a nasogastric tube, mix the contents of the capsule with 40 mL of apple juice and inject through the nasogastric tube. Flush nasogastric tube with additional juice to clear the tube. Alternatively, the orally disintegrating tablet may be placed in a syringe and then dissolved in water. After gently shaking the syringe for a quick dispersal, administer the contents within 15 minutes, followed by a small amount of water to rinse syringe and retrieve any remaining content.

The delayed-release oral suspension should be mixed with water only. Do not give through enteral administration tubes.

The orally disintegrating tables should not be chewed or swallowed intact.

The solu-tabs are available for administration via oral syringe or via nasogastric tube (>= 8 French).

Lansoprazole intravenous injection requires the use of in-line filter.

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