Kaletra Dosage
Generic name: lopinavir and ritonavir
Dosage form: Oral Solution
See also:
This dosage information does not include all the information needed to use Kaletra safely and effectively. See full prescribing information for Kaletra.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
KALETRA capsules and oral solution must be taken with food.
The recommended oral dose of KALETRA is as follows: (Please also refer to INDICATIONS AND USAGE and ADVERSE REACTIONS)
Adults
Therapy-Naïve Patients
- KALETRA 400/100 mg (3 capsules or 5.0 mL) twice-daily taken with food.
- KALETRA 800/200 mg (6 capsules or 10 mL) once-daily taken with food.
Therapy-experienced Patients
- KALETRA 400/100 mg (3 capsules or 5.0 mL) twice-daily taken with food.
Once-daily administration of KALETRA is not recommended in therapy-experienced patients.
Concomitant therapy: Efavirenz, nevirapine, amprenavir or nelfinavir
A dose increase of KALETRA to 533/133 mg (4 capsules or 6.5 mL) twice-daily taken with food is recommended when used in combination with efavirenz, nevirapine, amprenavir or nelfinavir (see CLINICAL PHARMACOLOGY– Drug-drug Interactions and/or PRECAUTIONS – Table 11).
KALETRA should not be administered as a once-daily regimen in combination with efavirenz, nevirapine, amprenavir or nelfinavir.
Pediatric Patients
In children 6 months to 12 years of age, the recommended dosage of KALETRA oral solution is 12/3 mg/kg for those 7 to < 15 kg and 10/2.5 mg/kg for those 15 to 40 kg (approximately equivalent to 230/57.5 mg/m2) twice-daily taken with food, up to a maximum dose of 400/100 mg in children > 40 kg (5.0 mL or 3 capsules) twice-daily. KALETRA once-daily has not been evaluated in pediatric patients. It is preferred that the prescriber calculate the appropriate milligram dose for each individual child ≤ 12 years old and determine the corresponding volume of solution or number of capsules. However, as an alternative, the following table contains dosing guidelines for KALETRA oral solution based on body weight. When possible, dose should be administered using a calibrated dosing syringe.
| Weight (kg) |
Dose (mg/kg)* |
Volume of oral solution BID (80 mg lopinavir/20 mg ritonavir per mL) |
|
* Dosing based on the lopinavir component of lopinavir/ritonavir solution (80 mg/20 mg per mL). |
||
| Without nevirapine, efavirenz or amprenavir | ||
| 7 to < 15 kg | 12 mg/kg BID | |
| 7 to 10 kg | 1.25 mL | |
| > 10 to < 15 kg | 1.75 mL | |
| 15 to 40 kg | 10 mg/kg BID | |
| 15 to 20 kg | 2.25 mL | |
| > 20 to 25 kg | 2.75 mL | |
| > 25 to 30 kg | 3.5 mL | |
| > 30 to 35 kg | 4.0 mL | |
| > 35 to 40 kg | 4.75 mL | |
| > 40 kg | Adult dose | 5 mL (or 3 capsules) |
Note: Use adult dosage recommendation for children > 12 years of age.
Concomitant Therapy: Efavirenz, nevirapine or amprenavir
A dose increase of KALETRA oral solution to 13/3.25 mg/kg for those 7 to < 15 kg and 11/2.75 mg/kg for those 15 to 45 kg (approximately equivalent to 300/75 mg/m2) twice-daily taken with food, up to a maximum dose of 533/133 mg in children > 45 kg twice-daily is recommended when used in combination with efavirenz, nevirapine or amprenavir in children 6 months to 12 years of age. The following table contains dosing guidelines for KALETRA oral solution based on body weight, when used in combination with efavirenz, nevirapine or amprenavir in children (see CLINICAL PHARMACOLOGY– Drug-drug Interactions and/or PRECAUTIONS – Table 11 ).
| Weight (kg) |
Dose (mg/kg)* |
Volume of oral solution BID (80 mg lopinavir/20 mg ritonavir per mL) |
|
* Dosing based on the lopinavir component of lopinavir/ritonavir solution (80 mg/20 mg per mL). |
||
| With nevirapine, efavirenz or amprenavir | ||
| 7 to < 15 kg | 13 mg/kg BID | |
| 7 to 10 kg | 1.5 mL | |
| > 10 to < 15 kg | 2.0 mL | |
| 15 to 45 kg | 11 mg/kg BID | |
| 15 to 20 kg | 2.5 mL | |
| > 20 to 25 kg | 3.25 mL | |
| > 25 to 30 kg | 4.0 mL | |
| > 30 to 35 kg | 4.5 mL | |
| > 35 to 40 kg | 5.0 mL (or 3 capsules) | |
| > 40 to 45 kg | 5.75 mL | |
| > 45 kg | Adult dose | 6.5 mL (or 4 capsules) |
Note: Use adult dosage recommendation for children > 12 years of age.
