Isoproterenol Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Asthma - Acute

Hand-bulb nebulizer: The 1:200 solution administered in a dose of 5 to 15 deep inhalations. In adults, the 1:100 solution in a dose of 3 to 7 deep inhalations may be used if a stronger solution is desired. If after 5 to 10 minutes inadequate relief is observed, these doses may be repeated one more time. If the acute attack recurs, treatments may be repeated up to 5 times daily if necessary.
Inhalation Aerosol: Inhale one activation and wait one full minute before considering a second inhalation. A treatment may be repeated up to 5 times daily if necessary.

Usual Adult Dose for Chronic Obstructive Pulmonary Disease - Acute

Hand-bulb nebulizer: The 1:200 solution administered in a dose of 5 to 15 deep inhalations. In adults, the 1:100 solution in a dose of 3 to 7 deep inhalations may be used if a stronger solution is desired. If after 5 to 10 minutes inadequate relief is observed, these doses may be repeated one more time. If the acute attack recurs, treatments may be repeated up to 5 times daily if necessary.
Nebulization By Compressed Air Or Oxygen--A method often used in patients with severe COPD is to deliver the isoproterenol mist in more dilute form over a longer period of time. The purpose is to achieve progressively deeper bronchodilation and thus insure that the mist achieves maximum penetration of the finer bronchioles. In this method, 0.5 mL of a 1:200 solution of isoproterenol is diluted to 2 to 2.5 mL with water or saline to achieve a concentration of 1:800 to 1:1000. If desired, 0.25 mL of the 1:100 solution may be similarly diluted to achieve the same concentration. The diluted solution is placed in a nebulizer connected to either a source of compressed air or oxygen. The flow rate is regulated so that the diluted solution of isoproterenol will be delivered over approximately 10 to 20 minutes. A treatment may be repeated up to 5 times daily if necessary. Although the total delivered dose of isoproterenol is somewhat higher than with the treatment regimen employing the hand-bulb nebulizer, patients usually tolerate it well because of the greater dilution and longer application-time factors.
Intermittent positive pressure breathing (IPPB): 0.5 mL of a 1:200 solution diluted to 2 to 2.5 mL with water or isotonic saline. Deliver over 15 to 20 minutes. May repeat up to 5 times daily.
Inhalation Aerosol: Inhale one or two activations. Repeat at no less than 3 to 5 hour intervals (6 to 8 times daily).

Usual Adult Dose for Bronchospasm During Anesthesia

IV Bolus: Dilute 1 mL (0.2 mg) to 10 mL with Sodium Chloride, or 5% Dextrose Injection and administer 0.01 to 0.02 mg (0.5 to 1 mL of diluted solution).
The initial dose may be repeated when necessary.

Usual Adult Dose for Shock

IV infusion: Dilute 5 mL (1 mg) in 500 mL of 5% Dextrose Injection and administer 0.5 to 5 mcg/min (0.25 to 2.5 mL of diluted solution).
Concentrations up to 10 times greater have been used when limitation of volume is essential. Rates over 30 mcg/min have been used in advanced stages of shock. The rate of infusion should be adjusted on the basis of heart rate, CVP, systemic blood pressure, and urine flow. If the heart rate exceeds 110 beats per minute, it may be advisable to decrease
or temporarily discontinue the infusion.

Usual Adult Dose for Adams-Stokes Syndrome

IV Bolus: Dilute 1 mL (0.2 mg) to 10 mL with Sodium Chloride, or 5% Dextrose Injection and administer 0.02 to 0.06 mg (1-3 mL of diluted solution).
Subsequent dose range is 0.01 to 0.2 mg (0.5 to 10 mL of diluted solution).
IV infusion: Dilute 10 mL (2 mg) in 500 mL of 5% Dextrose Injection and administer at 5 mcg/min. (1.25 mL of diluted solution/min).
Intramuscular: Use 1:5000 solution undiluted and administer 0.2 mg (1 mL).
Subsequent dose range is 0.02 to 1 mg (0.1 to 5 mL)
Subcutaneous: Use 1:5000 solution undiluted and administer 0.2 mg (1 mL).
Subsequent dose range is 0.15 to 0.2 mg (0.75 to 1 mL).
Intracardiac: Use 1:5000 solution undiluted and administer 0.02 mg (0.1 mL)

Usual Adult Dose for AV Heart Block

IV Bolus: Dilute 1 mL (0.2 mg) to 10 mL with Sodium Chloride, or 5% Dextrose Injection and administer 0.02 to 0.06 mg (1-3 mL of diluted solution).
Subsequent dose range is 0.01 to 0.2 mg (0.5 to 10 mL of diluted solution).
IV infusion: Dilute 10 mL (2 mg) in 500 mL of 5% Dextrose Injection and administer at 5 mcg/min. (1.25 mL of diluted solution/min).
Intramuscular: Use 1:5000 solution undiluted and administer 0.2 mg (1 mL).
Subsequent dose range is 0.02 to 1 mg (0.1 to 5 mL)
Subcutaneous: Use 1:5000 solution undiluted and administer 0.2 mg (1 mL).
Subsequent dose range is 0.15 to 0.2 mg (0.75 to 1 mL).
Intracardiac: Use 1:5000 solution undiluted and administer 0.02 mg (0.1 mL)

Usual Pediatric Dose for Asthma - Acute

Hand-bulb nebulizer: The 1:200 solution administered in a dose of 5 to 15 deep inhalations. Do not use more than 0.25 mL of the 1:200 solution for each of the 10 to 15 minute programmed treatments. If after 5 to 10 minutes inadequate relief is observed, these doses may be repeated one more time. If the acute attack recurs, treatments may be repeated up to 5 times daily if necessary.
Inhalation Aerosol: Inhale one activation and wait one full minute before considering a second inhalation. A treatment may be repeated up to 5 times daily if necessary.

Usual Pediatric Dose for Cardiac Arrhythmia

Neonates, infants, and children: 0.05 to 2 mcg/kg/min.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available

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