Isentress Dosage
Generic name: raltegravir
Dosage form: tablet, film coated; tablet, chewable
This dosage information does not include all the information needed to use Isentress safely and effectively. See full prescribing information for Isentress.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
General Dosing Recommendations
- ​ISENTRESS Film-Coated Tablets and Chewable Tablets can be administered with or without food [see Clinical Pharmacology (12.3)].
- ​Maximum dose of chewable tablets is 300 mg twice daily.
- ​ISENTRESS Chewable Tablets may be chewed or swallowed whole.
- ​ISENTRESS Film-Coated Tablets must be swallowed whole.
- ​Because the formulations are not bioequivalent, do not substitute chewable tablets for the 400 mg film-coated tablet.
- ​During coadministration of ISENTRESS 400 mg film-coated tablets with rifampin, the recommended dosage of ISENTRESS is 800 mg twice daily in adults. There are no data to guide co-administration of ISENTRESS with rifampin in patients below 18 years of age [see Drug Interactions (7)].
Adults
​For the treatment of adult patients with HIV-1 infection, the dosage of ISENTRESS is one 400 mg film-coated tablet administered orally, twice daily.
Pediatrics
​For the treatment of children and adolescents with HIV-1 infection, the dosage of ISENTRESS is as follows:
- ​12 years of age and older: One 400 mg film-coated tablet orally, twice daily
- ​6 to less than 12 years of age:
If at least 25 kg in weight:- ​One 400 mg film-coated tablet orally, twice daily OR
- ​Chewable tablets: weight based to maximum dose 300 mg, twice daily as specified in Table 1
- ​Chewable tablets: weight based to maximum dose 300 mg, twice daily as specified in Table 1
- ​2 to less than 6 years of age:
If at least 10 kg in weight:- ​Chewable tablets: weight based to maximum dose 300 mg, twice daily as specified in Table 1
| ​Body Weight (kg) |
Dose | Number of Chewable Tablets |
|---|---|---|
| 10 to less than 14 | 75 mg twice daily | 3 × 25 mg twice daily |
| 14 to less than 20 | 100 mg twice daily | 1 × 100 mg twice daily |
| 20 to less than 28 | 150 mg twice daily | 1.5 × 100 mg† twice daily |
| 28 to less than 40 | 200 mg twice daily | 2 × 100 mg twice daily |
| at least 40 | 300 mg twice daily | 3 × 100 mg twice daily |
