Isentress Dosage

General Dosing Recommendations

• ISENTRESS Film-Coated Tablets and Chewable Tablets can be administered with or without food [see Clinical Pharmacology (12.3)].
• Maximum dose of chewable tablets is 300 mg twice daily.
• ISENTRESS Chewable Tablets may be chewed or swallowed whole.
• ISENTRESS Film-Coated Tablets must be swallowed whole.
• Because the formulations are not bioequivalent, do not substitute chewable tablets for the 400 mg film-coated tablet.
• During coadministration of ISENTRESS 400 mg film-coated tablets with rifampin, the recommended dosage of ISENTRESS is 800 mg twice daily in adults. There are no data to guide co-administration of ISENTRESS with rifampin in patients below 18 years of age [see Drug Interactions (7)].

Adults

For the treatment of adult patients with HIV-1 infection, the dosage of ISENTRESS is one 400 mg film-coated tablet administered orally, twice daily.

Pediatrics

For the treatment of children and adolescents with HIV-1 infection, the dosage of ISENTRESS is as follows:

• 12 years of age and older: One 400 mg film-coated tablet orally, twice daily
• 6 to less than 12 years of age:
  If at least 25 kg in weight:
  • One 400 mg film-coated tablet orally, twice daily OR
  • Chewable tablets: weight based to maximum dose 300 mg, twice daily as specified in Table 1
  If less than 25 kg in weight:
  • Chewable tablets: weight based to maximum dose 300 mg, twice daily as specified in Table 1
• 2 to less than 6 years of age:
  If at least 10 kg in weight:
  • Chewable tablets: weight based to maximum dose 300 mg, twice daily as specified in Table 1