Isentress Dosage

Generic name: raltegravir
Dosage form: tablet, film coated; tablet, chewable

This dosage information does not include all the information needed to use Isentress safely and effectively. See full prescribing information for Isentress.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

General Dosing Recommendations

  • ISENTRESS Film-Coated Tablets and Chewable Tablets can be administered with or without food [see Clinical Pharmacology (12.3)].
  • Maximum dose of chewable tablets is 300 mg twice daily.
  • ISENTRESS Chewable Tablets may be chewed or swallowed whole.
  • ISENTRESS Film-Coated Tablets must be swallowed whole.
  • Because the formulations are not bioequivalent, do not substitute chewable tablets for the 400 mg film-coated tablet.
  • During coadministration of ISENTRESS 400 mg film-coated tablets with rifampin, the recommended dosage of ISENTRESS is 800 mg twice daily in adults. There are no data to guide co-administration of ISENTRESS with rifampin in patients below 18 years of age [see Drug Interactions (7)].

Adults

For the treatment of adult patients with HIV-1 infection, the dosage of ISENTRESS is one 400 mg film-coated tablet administered orally, twice daily.

Pediatrics

For the treatment of children and adolescents with HIV-1 infection, the dosage of ISENTRESS is as follows:

  • 12 years of age and older: One 400 mg film-coated tablet orally, twice daily
  • 6 to less than 12 years of age:
    If at least 25 kg in weight:
    • One 400 mg film-coated tablet orally, twice daily OR
    • Chewable tablets: weight based to maximum dose 300 mg, twice daily as specified in Table 1
    If less than 25 kg in weight:
    • Chewable tablets: weight based to maximum dose 300 mg, twice daily as specified in Table 1
  • 2 to less than 6 years of age:
    If at least 10 kg in weight:
    • Chewable tablets: weight based to maximum dose 300 mg, twice daily as specified in Table 1
Table 1: Recommended Dose* for ISENTRESS Chewable Tablets in Pediatric Patients 2 to Less Than 12 Years of Age
Body Weight
(kg)
Dose Number of Chewable Tablets
*
The weight-based dosing recommendation for the chewable tablet is based on approximately 6 mg/kg/dose twice daily.
The 100 mg chewable tablet can be divided into equal halves.
10 to less than 14 75 mg twice daily 3 × 25 mg twice daily
14 to less than 20 100 mg twice daily 1 × 100 mg twice daily
20 to less than 28 150 mg twice daily 1.5 × 100 mg twice daily
28 to less than 40 200 mg twice daily 2 × 100 mg twice daily
at least 40 300 mg twice daily 3 × 100 mg twice daily

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