Irbesartan Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Diabetic Nephropathy

Initial dose: 150 mg orally once a day with or without food.
Maintenance dose: 150 to 300 mg orally once a day.

Usual Adult Dose for Hypertension

Initial dose: 150 mg orally once a day with or without food.
Maintenance dose: 150 to 300 mg orally once a day.

Usual Pediatric Dose for Hypertension

6 to 12 years:
Initial dose: 75 mg once daily.
Maintenance dose: 75 mg to 150 mg once daily.

13 to 18 years:
Initial dose: 150 mg once daily.
Maintenance dose: 150 mg to 300 mg once daily.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Dose Adjustments

The initial dose should be decreased to 75 mg in patients with intravascular volume depletion.

Dialysis

Irbesartan is not removed by hemodialysis. An increased risk of hypotension exists if the dose is given immediately following dialysis. Ideally, the drug should be given when the patient is hemodynamically stable. The initial dose should be decreased to 75 mg in patients on dialysis.

Other Comments

If blood pressure is not controlled by irbesartan alone, a diuretic may be added.

Compared with Caucasian patients, Black patients have a reduced blood pressure response to monotherapy with angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers; however, the reduced response is largely eliminated if combination therapy that includes an adequate dose of a diuretic is instituted.

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