Iprivask Dosage

Generic name: desirudin
Dosage form: subcutaneous injection

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

2.1 Recommended Dose

All patients should be evaluated for bleeding disorder risk before prophylactic administration of Iprivask [see DRUG INTERACTIONS (7)].

Initial Dosage: In patients undergoing hip replacement surgery, the recommended dose of Iprivask is 15 mg every 12 hours administered by subcutaneous injection with the initial dose given up to 5 to 15 minutes prior to surgery, but after induction of regional block anesthesia, if used [see WARNINGS AND PRECAUTIONS, Spinal/Epidural Anesthesia (5.1)]. Up to 12 days administration (average duration 9 to 12 days) of Iprivask has been well tolerated in controlled clinical trials.

2.2 Dose in Renal Impairment

Degree of Renal
Impairment
Creatinine
Clearance
[mL/min/1.73m2 body surface area]
aPTT Monitoring & Dosing Instructions
Moderate ≥31 to 60 Initiate therapy at 5 mg every 12 hours by subcutaneous injection.  Monitor aPTT and serum creatinine at least daily. If aPTT exceeds 2 times control:
1. Interrupt therapy until the value returns to less than 2 times control.
2. Resume therapy at a reduced dose guided by the initial degree of aPTT abnormality
Severea <31 Initiate therapy at 1.7 mg every 12 hours by subcutaneous injection. Monitor aPTT and serum creatinine at least daily. If aPTT exceeds 2 times control:
1. Interrupt therapy until the value returns to less than 2 times control.
2. Consider further dose reductions guided by the initial degree of aPTT abnormality

a See CLINICAL PHARMACOLOGY, Pharmacokinetics, Renal Impairment (12.3) and WARNINGS AND PRECAUTIONS, Renal Impairment (5.2).

2.3 Dose in Hepatic Impairment

In the absence of clinical studies in this population, dosing recommendations cannot be made at this time [see CLINICAL PHARMACOLOGY, Hepatic Impairment (12.3.) and WARNINGS AND PRECAUTIONS (5.5)].

2.4 Instructions for Administration

Directions on Preparation

Use Iprivask before the expiration date given on the carton and container.

  1. Reconstitution should be carried out under sterile conditions.
  2. Remove plastic flip-top cap from Iprivask Vial. Remove back cover of Vial Adapter package. Attach Vial Adapter to Vial by using the outer package to handle Adapter. Push Adapter down onto Vial until spike pierces rubber stopper and snaps into place. Discard Vial Adapter package.
  3. Remove Syringe cap by twisting and pulling gently. Attach Syringe to Adapter on Vial by twisting. Slowly push plunger down to completely transfer solution into Vial. Leaving Syringe connected to Vial, gently swirl. Lyophilized powder in Vial will dissolve within 10 seconds.
  4. With Syringe still connected to Vial, turn Vial upside down and withdraw entire contents of Vial back into Syringe. Remove Syringe from Vial and hold it with plunger-end down.
  5. You must use enclosed Eclipse needle. Attach Needle to Syringe by twisting. Pull pink lever down and uncap needle. You are ready to inject Iprivask. After injection, flip up pink lever to cover needle until it snaps into place. Dispose of the used Syringe in a Sharps® container.

Iprivask should not be mixed with other injections, solvents, or infusions. Iprivask is administered by subcutaneous injection. It must not be administered by intramuscular injection.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

Subcutaneous Injection Technique: Patients should be sitting or lying down and Iprivask injection administered by deep subcutaneous injection. Administration should be alternated between the left and right anterolateral and left and right posterolateral thigh or abdominal wall. The whole length of the needle should be introduced into a skin fold held between the thumb and forefinger; the skin fold should be held throughout the injection. To minimize bruising, do not rub the injection site after completion of the injection.

2.5 Storage after Reconstitution

Once Iprivask is reconstituted it may be used for up to 24 hours, when stored at 25°C (77°F); excursions permitted to 15–30°C (59-86°F). [See USP Controlled Room Temperature.]. Protect from light. After 24 hours, discard the solution. 

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