Insulin Detemir Dosage

Usual Adult Dose for Diabetes Mellitus Type II

For patients with type 1 or type 2 diabetes receiving basal and bolus insulin injections, changing the basal insulin to insulin detemir can be done on a unit-to-unit basis. The dose of insulin detemir should then be adjusted to achieve glycemic targets.

For patients currently receiving only basal insulin, changing the basal insulin to insulin detemir can be done on a unit-to-unit basis.

For insulin-naive patients with type 2 diabetes who are inadequately controlled on oral antidiabetic drugs, insulin detemir should be started at a dose of 0.1 to 0.2 units/kg subcutaneously once daily in the evening. Alternatively, patients may be started with 10 units subcutaneously once or twice daily and the adjusted to achieve glycemic goals.

Usual Adult Dose for Diabetes Mellitus Type I

For patients with type 1 or type 2 diabetes receiving basal and bolus insulin injections, changing the basal insulin to insulin detemir can be done on a unit-to-unit basis. The dose of insulin detemir should then be adjusted to achieve glycemic targets.

For patients currently receiving only basal insulin, changing the basal insulin to insulin detemir can be done on a unit-to-unit basis.

For insulin-naive patients with type 2 diabetes who are inadequately controlled on oral antidiabetic drugs, insulin detemir should be started at a dose of 0.1 to 0.2 units/kg subcutaneously once daily in the evening. Alternatively, patients may be started with 10 units subcutaneously once or twice daily and the adjusted to achieve glycemic goals.

Usual Pediatric Dose for Diabetes Mellitus Type II

For patients with type 1 or type 2 diabetes receiving basal and bolus insulin injections, changing the basal insulin to insulin detemir can be done on a unit-to-unit basis. The dose of insulin detemir should then be adjusted to achieve glycemic targets.

For patients currently receiving only basal insulin, changing the basal insulin to insulin detemir can be done on a unit-to-unit basis.

For insulin-naive patients with type 2 diabetes who are inadequately controlled on oral antidiabetic drugs, insulin detemir should be started at a dose of 0.1 to 0.2 units/kg subcutaneously once daily in the evening. Alternatively, patients may be started with 10 units subcutaneously once or twice daily and the adjusted to achieve glycemic goals.

Usual Pediatric Dose for Diabetes Mellitus Type I

For patients with type 1 or type 2 diabetes receiving basal and bolus insulin injections, changing the basal insulin to insulin detemir can be done on a unit-to-unit basis. The dose of insulin detemir should then be adjusted to achieve glycemic targets.

For patients currently receiving only basal insulin, changing the basal insulin to insulin detemir can be done on a unit-to-unit basis.

For insulin-naive patients with type 2 diabetes who are inadequately controlled on oral antidiabetic drugs, insulin detemir should be started at a dose of 0.1 to 0.2 units/kg subcutaneously once daily in the evening. Alternatively, patients may be started with 10 units subcutaneously once or twice daily and the adjusted to achieve glycemic goals.

Renal Dose Adjustments

Decreased dosage may be required. Careful blood glucose monitoring and dose adjustment are recommended.

Liver Dose Adjustments

Decreased dosage may be required. Careful blood glucose monitoring and dose adjustment are recommended.

Dose Adjustments

Daily insulin requirements may be higher during illness, stress, pregnancy, in obese patients, trauma, during concurrent use with medications having hyperglycemic effects, or after surgery, and lower with exercise, weight loss, calorie restricted diets, or during concurrent use of medications having hypoglycemic effects. Total daily doses should not be adjusted by more than 10% increments.

Supplemental doses may be prescribed during illness or to correct high preprandial blood glucose.

Dosage adjustments may be required when the brand, type, or species of insulin is changed.

Precautions

Insulin detemir should not be mixed or diluted with any other insulin preparations.

Dialysis

Data not available

Other Comments

At least twice weekly blood glucose monitoring is recommended for type I and II diabetes on conventional insulin therapy. Blood glucose is measured 3 or more times daily before meals during intensive insulin regimens. More frequent monitoring is necessary during illness or stress.

Urine ketone testing is recommended for patients with type I diabetes if they develop symptoms of colds, influenza, nausea, vomiting, or other illnesses, polyuria, or if blood glucose levels are unexpectedly high or inconsistent.

Glycosylated hemoglobin measurements are recommended every 3 months.

At least yearly serum creatinine, BUN, ECG determinations, and ophthalmologic examinations are recommended.

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