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Imipramine Dosage

Applies to the following strength(s): 50 mg ; 25 mg ; pamoate 75 mg ; pamoate 150 mg ; 10 mg ; pamoate 100 mg ; pamoate 125 mg ; 12.5 mg/mL

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Geriatric Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Depression

Tablets:
Hospitalized Patients:
Initial dose: 100 mg orally per day
Maintenance dose: 100 to 200 mg orally per day (If no response after 2 weeks, increase to 250 to 300 mg per day)
Maximum dose: 300 mg orally per day

Outpatients:
Initial dose: 75 mg orally per day
Maintenance dose: 50 to 150 mg orally per day
Maximum dose: 200 mg orally per day

Capsules:
Hospitalized Patients:
Initial dose: 100 to 150 mg orally per day
Maintenance dose: 75 to 150 mg orally per day
Maximum dose: 300 mg orally per day

Outpatients:
Initial dose: 75 mg orally per day
Maintenance dose: 75 to 150 mg orally per day
Maximum dose: 200 mg orally per day

Comments:
-The daily dosage may be given at bedtime or in divided doses.
-In cases of relapse due to premature withdrawal of the drug, the effective dosage should be reinstituted.

Use:
-Relief of symptoms of depression

Usual Geriatric Dose for Depression

Tablets:
Initial dose: 30 to 40 mg orally per day
Maximum dose: 100 mg orally per day

Capsules:
Initial dose: 25 to 50 mg orally per day
Maximum dose: 100 mg orally per day

Comments:
-Capsules may be used when total daily dosage is established at 75 mg or higher.
-The daily dosage may be given at bedtime or in divided doses.
-In cases of relapse due to premature withdrawal of the drug, the effective dosage should be reinstituted.

Use:
-Relief of symptoms of depression

Usual Pediatric Dose for Enuresis

Tablets:
6 years to 12 years:
Initial dose: 25 mg orally per day
Maintenance dose: 50 mg orally per day
Maximum dose: 2.5 mg/kg/day

12 years to 18 years:
Initial dose: 25 mg orally per day
Maintenance dose: 75 mg orally per day
Maximum dose: 2.5 mg/kg/day

Comments:
-This dose should be given one hour before bedtime.
-In early night bedwetters, the drug is more effective given earlier and in divided amounts, i.e., 25 mg in mid afternoon, repeated at bedtime.
-Dosage should be tapered off gradually.

Use: Temporary adjunctive therapy in reducing enuresis in children aged 6 years and older

Renal Dose Adjustments

Renal dysfunction: Use with caution

Liver Dose Adjustments

Hepatic dysfunction: Use with caution

Dose Adjustments

-Dosage adjustment may be required when given concomitantly with methylphenidate.
-Dosage adjustment may be required when given concomitantly with hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) or enzyme inducers (e.g., barbiturates, phenytoin).
-Dosage adjustment may be required when given concomitantly with anticholinergic drugs.

Precautions

BOXED WARNING(S):
Suicidality and Antidepressant Drugs
-Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders.
-Anyone considering the use of this drug or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24. There was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older.
-Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber.
-This drug is not approved for use in pediatric patients.

-Safety and effectiveness in the pediatric population other than pediatric patients with nocturnal enuresis have not been established
-Safety and effectiveness for nocturnal enuresis in pediatric patients less than 6 years of age has not been established

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Monitoring:
-Psychiatric: Patients should be monitored for worsening and emergence of suicidal thoughts.

Patient advice:
-Patients should be cautioned accordingly since this drug may impair the mental and/or physical abilities required for the performance of operating an automobile or machinery.

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