Hydralazine/Isosorbide Dinitrate Dosage
This dosage information may not include all the information needed to use Hydralazine/Isosorbide Dinitrate safely and effectively. See additional information for Hydralazine/Isosorbide Dinitrate.
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Congestive Heart Failure
Initial: 1 tablet (37.5 mg-20 mg) orally three times a day.
The initial dose may be titrated to a maximum tolerated dose not to exceed two tablets three times a day. Although titration can be rapid (3 to 5 days), some patients experience side effects and may take longer to reach their maximum tolerated dose.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Dose Adjustments
The dose may be decreased to as little as one-half tablet three times a day if intolerable side effects occur and efforts should be made to titrate up as soon as side effects subside.
Precautions
Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
Dialysis
Data not available
Other Comments
There is no adequate experience in heart failure with doses of the combination product other than those recommended and no experience with the use of the individual components.
The combination of hydralazine-isosorbide dinitrate, in addition to standard therapy, is a reasonable alternative in patients with chronic heart failure who cannot be given an angiotensin converting enzyme inhibitor or an angiotensin II receptor blocker because of drug intolerance, lack of efficacy, hypotension, or renal insufficiency.
The combination of hydralazine-isosorbide dinitrate is particularly effective in black patients with heart failure who tend to be less responsive to angiotensin-converting enzyme inhibitors, which are part of standard therapy for heart failure.
