Humulin R Dosage
Generic name: insulin human 100[iU] in 1mL
Dosage form: injection, solution
Drug class: Insulin
Medically reviewed by Drugs.com. Last updated on Jun 20, 2023.
Important Administration Instructions
- Always check the insulin label before administration to confirm the correct insulin product is being used [see Warnings and Precautions (5.4)].
- Inspect HUMULIN R visually before use. It should appear clear and colorless. Do not use HUMULIN R if particulate matter or coloration is seen.
Route of Administration
Subcutaneous Injection
- Inject HUMULIN R subcutaneously approximately 30 minutes before meals into the thigh, upper arm, abdomen, or buttocks.
- Rotate injection sites within the same region from one injection to the next to reduce the risk of lipodystrophy and localized cutaneous amyloidosis. Do not inject into areas of lipodystrophy or localized cutaneous amyloidosis [see Warnings and Precautions (5.2) and Adverse Reactions (6)].
- HUMULIN R may be diluted with Sterile Diluent for HUMULIN R for subcutaneous injection ONLY under medical supervision.
- Dilute one part HUMULIN R to nine parts diluent to yield a concentration one-tenth that of HUMULIN R (equivalent to U-10).
- Dilute one part HUMULIN R to one part diluent to yield a concentration one-half that of HUMULIN R (equivalent to U-50).
- Diluted HUMULIN R may be used for 28 days when stored at 41°F (5°C) or for 14 days when stored at 86°F (30°C).
Intravenous Administration
- Administer HUMULIN R intravenously ONLY under medical supervision with close monitoring of blood glucose and potassium levels to reduce the risk of hypoglycemia and hypokalemia [see Warnings and Precautions (5.3, 5.6)].
- For intravenous use, HUMULIN R should be used at concentrations from 0.1 unit/mL to 1 unit/mL in infusion systems containing 0.9% Sodium Chloride Injection.
- Intravenous infusion bags prepared with HUMULIN R are stable when stored in a refrigerator (36° to 46°F [2° to 8°C]) for 48 hours and then may be used at room temperature for up to an additional 48 hours.
Dosing Instructions
- Individualize and adjust the dosage of HUMULIN R based on the route of administration, the patient's metabolic needs, blood glucose monitoring results, and glycemic control goal.
- HUMULIN R given by subcutaneous injection should generally be used in regimens with an intermediate- or long-acting insulin.
- During changes to a patient's insulin regimen, increase the frequency of blood glucose monitoring [see Warnings and Precautions (5.2)].
- Dosage adjustments may be needed with changes in physical activity, changes in meal patterns (e.g., macronutrient content or timing of food intake), changes in renal or hepatic function, or during acute illness [see Warnings and Precautions (5.2, 5.3), Use in Specific Populations (8.6, 8.7)].
- Dosage adjustment may be needed when changing from another insulin to HUMULIN R [see Warnings and Precautions (5.2)].
Dosage Adjustment due to Drug Interactions
- Dosage adjustment may be needed when HUMULIN R is co-administered with certain drugs [see Drug Interactions (7)].
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Patient resources
Other brands
Novolin R, Humulin R U-500 (Concentrated), Humulin R U-500 KwikPen, Myxredlin
Professional resources
Other brands
Novolin R, Humulin R U-500 (Concentrated)
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
