Horizant Dosage
Generic name: gabapentin enacarbil
Dosage form: tablet, extended release
This dosage information does not include all the information needed to use Horizant safely and effectively. See full prescribing information for Horizant.
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Restless Legs Syndrome
The recommended dosage for HORIZANT is 600 mg once daily taken with food at about 5 PM. A daily dose of 1,200 mg provided no additional benefit compared with the 600-mg dose, but caused an increase in adverse reactions [see Adverse Reactions (6.1)].
If the dose is not taken at the recommended time, the next dose should be taken the following day as prescribed.
Tablets should be swallowed whole and should not be cut, crushed, or chewed.
Renal Impairment
​ Dosing of HORIZANT is adjusted in accordance with renal function, as represented by creatinine clearance [see Clinical Pharmacology (12.3)]. Target dose regimens are listed in Table 1.
|
Creatinine Clearance (mL/min) |
Target Dose Regimen |
|
≥60 |
600 mg per day |
|
30-59 |
Start at 300 mg per day and increase to 600 mg as needed |
|
15-29 |
300 mg per day |
|
<15 |
300 mg every other day |
|
<15 on hemodialysis |
Not recommended |
In patients with stable renal function, CrCl can be estimated using the equation of Cockcroft and Gault:
for males: CrCl = (140-age)(weight)/[(72)(SCr)]
for females: CrCl = (0.85)(140-age)(weight)/[(72)(SCr)]
where age is in years, weight is in kilograms, and SCr is serum creatinine in mg/dL.
See also...
- Horizant Side Effects
- Horizant Drug Interactions
- Horizant (gabapentin) consumer information
- Gabapentin dosage information
- Gabapentin consumer information
- Gralise (gabapentin) dosage information
- Gralise (gabapentin) consumer information
- Neurontin (gabapentin) capsules, tablets, oral solution dosage information
- Neurontin (gabapentin) consumer information
