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Guanethidine / Hydrochlorothiazide Dosage

Applies to the following strengths: 10 mg-25 mg

Usual Adult Dose for Hypertension

Initial dose: 1 tablet orally once a day. Determine dosage by individual titration.
Maintenance dose: May increase to 2 tablets orally once a day.

Renal Dose Adjustments

Hydrochlorothiazide is generally not effective in patients with creatine clearance less than 25 mL/min. Thiazide diuretics should be used with caution in patients with severe renal disease.

Liver Dose Adjustments

Thiazide diuretics should be used with caution in patients with hepatic impairment.

Dose Adjustments

Dosage adjustments may occur every 2 to 3 weeks.

Dialysis

Data not available

Other Comments

If further blood pressure control is indicated, additional doses of guanethidine or other nondiuretic antihypertensive agents should be considered.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.