Glipizide Dosage

This dosage information may not include all the information needed to use Glipizide safely and effectively. See additional information for Glipizide.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Geriatric Dose for:

Additional dosage information:

Usual Adult Dose for Diabetes Type 2

Initial dose: 5 mg (immediate or sustained-release) orally once a day, 30 minutes before breakfast.
Maintenance dose: 2.5 to 30 mg (immediate-release) orally in 1 or 2 divided doses or 5 to 20 mg (sustained-release) orally in 1 or 2 divided doses.

Usual Geriatric Dose for Diabetes Type 2

Initial dose: 2.5 to 5 mg orally once a day. Doses may be increased in 1 or 2 week intervals in 2.5 to 5 mg/day increments.

Renal Dose Adjustments

Initial dose for patients with renal insufficiency (CrCl 25 to 49 mL/min) is 2.5 mg orally once a day. Glipizide is not recommended for use in severely renally impaired patients (CrCl less than 25 mL/min).

Liver Dose Adjustments

Initial dose: 2.5 mg orally once a day. Doses may be increased in 1 to 2 week intervals in 2.5 to 5 mg/day increments.

Dose Adjustments

Dosage adjustments should be made in no more than 2.5 to 5 mg increments every 5 to 7 days. Doses greater than 15 mg/day should generally be divided. Patients stabilized on immediate-release glipizide may be switched to sustained-release at the nearest total daily dose.

Precautions

Patients switched from longer acting agents, such as chlorpropamide, should be carefully monitored for hypoglycemia in the first 2 weeks of therapy.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

Immediate release: The maximum recommended once-daily dose is 15 mg; maximum recommended total daily dose is 40 mg.
Sustained release: The maximum daily dose is 20 mg.

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