Gadobutrol Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Vascular Magnetic Resonance Imaging

To detect and visualize areas with disrupted blood brain barrier (BBB) and/or abnormal vascularity of the central nervous system:
0.1 mL/kg body weight (0.1 mmol/kg) as an intravenous bolus injection, manually or by power injector, at a flow rate of approximately 2 mL/second. Flush the intravenous cannula with physiological saline solution after the injection.

Usual Pediatric Dose for Vascular Magnetic Resonance Imaging

2 years of age and older:
To detect and visualize areas with disrupted blood brain barrier (BBB) and/or abnormal vascularity of the central nervous system:
0.1 mL/kg body weight (0.1 mmol/kg) as an intravenous bolus injection, manually or by power injector, at a flow rate of approximately 2 mL/second. Flush the intravenous cannula with physiological saline solution after the injection.

Renal Dose Adjustments

No dosage adjustment is recommended for patients with renal impairment (see precautions).

Liver Dose Adjustments

Data not available

Precautions

Prior to administration, all patients should be screened for renal dysfunction by obtaining a history and/or laboratory tests. Gadolinium based contrast agents increase the risk for nephrogenic systemic fibrosis (NSF) in patients with acute or chronic severe renal insufficiency (glomerular filtration rate less than 30 mL/min/1.73 m2), or acute renal insufficiency of any severity due to surgery, severe infection, injury or drug-induced kidney toxicity. In these patients, avoid use of gadolinium based contrast agents unless the diagnostic information is essential and not available with noncontractile enhanced magnetic resonance imaging (MRI).

Dialysis

Gadobutrol can be removed from the body by hemodialysis. For patients receiving hemodialysis, physicians may consider the prompt initiation of hemodialysis following the administration in order to enhance elimination.

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