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Fluvoxamine Dosage

Applies to the following strength(s): 25 mg ; 50 mg ; 100 mg ; 150 mg

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Obsessive Compulsive Disorder

Initial extended release capsule dose: 100 mg orally once a day at bedtime
Initial immediate release tablet dose: 50 mg orally once a day at bedtime
Maintenance dose: 100 to 300 mg orally per day. The dose may be increased in 50 mg increments every 4 to 7 days, as tolerated, until maximum therapeutic benefit is achieved.
Maximum Dose: 300 mg orally per day

Comments:
-A total daily dose of more than 100 mg should be given in two divided doses. If the doses are not equal, the larger dose should be given at bedtime.

Use: Treatment of obsessions and compulsions in patients with obsessive compulsive disorder (OCD), as defined in DSM-III-R or DSM-IV

Usual Pediatric Dose for Obsessive Compulsive Disorder

8 to 11 years:
Initial dose: 25 mg orally once a day at bedtime
Maintenance dose: 25 to 200 mg orally per day
Maximum dose: 200 mg orally per day

Comments:
-The dose may be increased in 25 mg increments every 4 to 7 days, as tolerated, up to a maximum dose of 200 mg per day.
-Total daily doses of more than 50 mg should be given in two divided doses. If the two divided doses are not equal, the larger dose should be given at bedtime.
-Lower doses may be effective in female compared to male patients.

11 to 17 years:
Initial dose: 25 mg orally once a day at bedtime
Maintenance dose: 25 to 300 mg orally per day. The dose may be increased in 25 mg increments every 4 to 7 days, as tolerated, up to a maximum dose of 300 mg per day.
Maximum dose: 300 mg orally per day

Comments:
-Total daily doses of more than 50 mg should be given in two divided doses. If the two divided doses are not equal, the larger dose should be given at bedtime.
-Lower doses may be effective in female versus male patients.

Use: Treatment of obsessions and compulsions in patients with obsessive compulsive disorder (OCD), as defined in DSM-III-R or DSM-IV

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

-Lower initial immediate release tablet doses (25 mg orally once a day) and slower titration may be advisable.
-Extended release capsules: It may be appropriate to titrate slowly following the initial dose of 100 mg.

Dose Adjustments

-It may be appropriate to reduce the initial dose and the subsequent dose titration for elderly patients and those with hepatic impairment.

Precautions

BOXED WARNING(S):
Suicidality and Antidepressant Drugs
-Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of fluvoxamine or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24. There was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older.
-Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber.
-This drug is not approved for use in pediatric patients except for patients with obsessive compulsive disorder (OCD).

Safety and efficacy in patients younger than 18 years other than pediatric patients with Obsessive Compulsive Disorder (OCD) have not been established.

Consult WARNINGS section for additional precautions.

Dialysis

Dialysis is not expected to remove this drug.

Other Comments

Administration advice:
-This drug should be swallowed whole and not chewed.
-Patients should be maintained on the lowest effective dose.

Monitoring:
-Psychiatric: Patients should be monitored for discontinuation symptoms, and for worsening and emergence of suicidal thoughts.
-Neurologic: Patients should be monitored for symptoms of serotonin syndrome.
-Cardiovascular: Patients should have regular monitoring of blood pressure.

Patient advice:
-Somnolence has been reported. Caution in driving and operating machinery is recommended until the individual response to the drug has been determined.

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