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Ferrous Sulfate Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Iron Deficiency Anemia

Initial: 300 to 325 mg of regular-release ferrous sulfate orally once a day.

Maintenance:
Regular-release ferrous sulfate: 325 mg orally 3 times a day. Alternatively, 300 mg orally 4 times a day may be given.
Extended-release ferrous sulfate: 160 mg orally 1 to 2 times a day.

Resolution of iron deficiency anemia may require ferrous sulfate supplementation for several weeks or months, depending on the duration and severity of the anemia.

Usual Adult Dose for Anemia Associated with Chronic Renal Failure

Initial: 300 to 325 mg of regular-release ferrous sulfate orally once a day.

Maintenance:
Regular-release ferrous sulfate: 325 mg orally 3 times a day. Alternatively, 300 mg orally 4 times a day may be given.
Extended-release ferrous sulfate: 160 mg orally 1 to 2 times a day.

A transferrin saturation of less than 20%, or a serum ferritin level of less than 100 mcg/L suggests inadequate iron stores and a need for iron replacement therapy.

Continued iron replacement therapy is needed in most patients receiving epoetin alfa treatment.

Usual Adult Dose for Vitamin/Mineral Supplementation during Pregnancy/Lactation

325 mg orally once a day.

The CDC has defined anemia during pregnancy as a hemoglobin concentration less than 100 g/L during the first and third trimesters and less than 105 g/L during the second trimester or a hematocrit value of less than 32%.

The recommended daily allowance (RDA) of elemental iron is 30 mg orally during pregnancy and 15 mg orally during lactation.

Usual Adult Dose for Vitamin/Mineral Supplementation

325 mg orally once a day.

The recommended daily allowance (RDA) of elemental iron is 10 mg for adult males, 15 mg for adult, premenopausal women, and 10 mg for postmenopausal women.

Usual Pediatric Dose for Iron Deficiency Anemia

Premature neonates:
2 to 4 mg elemental iron/kg/day divided every 12 to 24 hours (maximum daily dose = 15 mg).

Infants and children less than 12 years:
Prophylaxis: 1 to 2 mg elemental iron/kg/day (maximum 15 mg) in 1 to 2 divided doses.

Mild to moderate iron deficiency anemia:
3 mg elemental iron/kg/day in 1 to 2 divided doses.

Severe iron deficiency anemia:
4 to 6 mg elemental iron/kg/day in 3 divided doses.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Dialysis

Iron supplementation is routinely provided to peritoneal dialysis and hemodialysis patients for prevention or treatment of anemia associated with chronic renal failure.

Other Comments

Recommended Daily Allowance (RDA) of Iron:
1 to 5 months: 5 mg elemental iron
5 months to 10 years: 10 mg elemental iron
Male:
11 to 18 years: 12 mg elemental iron
8 years and older: 10 mg elemental iron
Female:
11 to 50 years: 15 mg elemental iron
50 years and older: 10 mg elemental iron

Multiple concentrations of ferrous sulfate oral liquid exist. Close attention should be paid to the concentration when ordering and administering ferrous sulfate. Incorrect selection or substitution of one ferrous sulfate liquid for another without proper dosage volume adjustment may result in serious over- or underdosing.

Iron supplements are generally better absorbed on an empty stomach, however, if gastric intolerance occurs, iron may be taken with food.

Liquid formulations of iron may stain teeth and should therefore be administered with a straw.

Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6 years. Keep this product out of reach of children. In case of accidental overdose, call a physician or poison control center immediately.

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