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Etoposide Dosage

Medically reviewed by Drugs.com. Last updated on Jul 25, 2023.

Applies to the following strengths: 20 mg/mL; 50 mg

Usual Adult Dose for Testicular Cancer

In combination with other approved chemotherapeutic agents:
50 to 100 mg/m2 IV over 30 to 60 minutes once a day on days 1 through 5 every 3 to 4 weeks to 100 mg/m2 IV over 30 to 60 minutes once a day on days 1, 3, and 5 every 3 to 4 weeks

Comments:


Use: In combination therapy with other approved chemotherapeutic agents in patients with refractory testicular tumors who have already received appropriate surgical, chemotherapeutic, and radiotherapeutic therapy

Usual Adult Dose for Small Cell Lung Cancer

IV:
In combination with other approved chemotherapeutic agents:
35 mg/m2 IV over 30 to 60 minutes once a day for 4 days to 50 mg/m2 IV over 30 to 60 minutes once a day for 5 days every 3 to 4 weeks

Oral:
In combination with other approved chemotherapeutic agents:
The recommended dose is 2 times the IV dose rounded to the nearest 50 mg (i.e., 2 times 35 mg/m2 IV once a day for 4 days to 50 mg/m2 IV once a day for 5 days equaling 70 mg/m2 orally once a day for 4 days to 100 mg/m2 orally once a day for 5 days)

Comments:


Use: In combination with other approved chemotherapeutic agents as first line treatment in patients with small cell lung cancer

Renal Dose Adjustments

CrCl greater than 50 mL/min: Administer 100% of the normal dose
CrCl 15 to 50 mL/min: Administer 75% of the normal dose
CrCl less than 15 mL/min: Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

The dose should be modified to consider the myelosuppressive effects of other drugs in the combination or the effects of prior X-ray therapy or chemotherapy which may have compromised bone marrow reserve.

Precautions

US BOXED WARNING:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Monitoring:

Reconstitution/preparation/storage advice:

General:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.