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Etoposide Dosage

Applies to the following strength(s): 20 mg/mL ; 50 mg

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Testicular Cancer

IV:
In combination with other approved chemotherapeutic agents:
50 to 100 mg/m2 IV once a day on days 1 through 5 to 100 mg/m2 IV once a day on days 1,3, and 5

Comments:
-The dosage should be modified to take into account the myelosuppressive effects of other drugs in the combination or the effects of prior x-ray therapy or chemotherapy which may have compromised bone marrow reserve.

Use: In combination therapy with other approved chemotherapeutic agents in patients with refractory testicular tumors who have already received appropriate surgical, chemotherapeutic, and radiotherapeutic therapy

Usual Adult Dose for Small Cell Lung Cancer

-IV:
In combination with other approved chemotherapeutic agents:
35 mg/m2 IV once a day for 4 days to 50 mg/m2 IV once a day for 5 days
-Oral:
In combination with other approved chemotherapeutic agents:
The recommended dose is two times the IV dose rounded to the nearest 50 mg (i.e., two times 35 mg/m2 IV once a day for 4 days to 50 mg/m2 IV once a day for 5 days equaling 70 mg/m2 orally once a day for 4 days to 100 mg/m2 orally once a day for 5 days)

Comments:
-The dosage should be modified to take into account the myelosuppressive effects of other drugs in the combination or the effects of prior x-ray therapy or chemotherapy which may have compromised bone marrow reserve.

Use: In combination with other approved chemotherapeutic agents as first line treatment in patients with small cell lung cancer.

Renal Dose Adjustments

IV OR ORAL FORMULATION:
CrCl less than 15 mL/min: Data not available
CrCl 15 to 50 mL/min: Administer 75% of the normal dose
CrCl greater than 50 mL/min: Administer 100% of the normal dose

Liver Dose Adjustments

IV OR ORAL FORMULATION: Data not available

Dose Adjustments

-The oral dose is twice the IV dose rounded to the nearest 50 mg and given in 2 divided doses if greater than 400 mg. Dosages of etoposide may vary based on specific indication for use and choice of cytotoxic agents coadministered. Reference to specific protocols is recommended. Dosages should be modified to take into account the myelosuppressive effects of other drugs in the combination or the effects of prior X-ray therapy or chemotherapy which may have compromised bone marrow reserve.
-Patients usually receive 3 to 4 cycles of chemotherapy. The dose and the number of cycles of therapy should be adjusted according to the level of bone marrow suppression and the reaction of the tumor.
-For patients receiving combination therapy, the myelosuppressive effects of radiation therapy or chemotherapy should be taken into account when determining the dosage of etoposide.

Precautions

US BOXED WARNING:
-This drug (whether given IV or orally) should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Severe myelosuppression with resulting infection or bleeding may occur.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Oral capsules should be administered on an empty stomach (1 hour before or 2 hours after food).

Monitoring:
-Patients should be frequently observed for myelosuppression both during and after therapy. Dose-limiting bone marrow suppression is the most significant toxicity. The platelet count, hemoglobin, white blood cell count, and differential should be obtained at the start of therapy and prior to each subsequent dose.

Reconstitution/preparation/storage advice:
-Consult the manufacturer product information.

Other:
-Courses of therapy may be repeated at 3 to 4 week intervals, after adequate recovery from toxicity.
-The parenteral formulation of this drug is for IV administration only and should not be mixed with any other drug.

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