Etidronate Dosage

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Usual Adult Dose for Hypercalcemia of Malignancy

Intravenous: 7.5 mg/kg (ideal body weight) intravenously by slow infusion over at least 2 hours once a day for 3 days (round dose to nearest 25 mg). Some patients have been treated for up to 7 days. To prolong the reduction in serum calcium, oral etidronate may be started on the day following the last intravenous dose. If significant hypercalcemia recurs, a second intravenous course for 3 days may be instituted. A minimum of 7 days should elapse between doses.

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Oral: 20 mg/kg (ideal body weight) orally once a day, 2 hours before or after meals for 30 days (round dose to nearest 200 mg). Therapy should be continued for 30 days. If the patient remains normocalcemic, treatment may be extended up to 90 days.

Food, milk products, vitamins, minerals, and antacids should not be administered within two hours of a dose of etidronate.

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30 mg/kg (ideal body weight, rounded to nearest 50 mg) by continuous intravenous infusion over 24 hours may be administered. This dosage appears to safe and effective and may be more convenient than standard therapy. However, this dosage of etidronate is not approved for the treatment of hypercalcemia of malignancy.

Usual Adult Dose for Paget's Disease

5 to 10 mg/kg (ideal body weight) orally once a day, 2 hours before or after meals for up to 6 months (round dose to nearest 200 mg). Therapy at this dosage range should not exceed 6 months.

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10 to 20 mg/kg (ideal body weight) orally (round dose to nearest 200 mg) once a day for up to 3 months if the patient has failed to respond to lower doses or requires suppression of rapid bone turnover.

Food, milk products, vitamins, minerals, and antacids should not be administered within two hours of a dose of etidronate.

Usual Adult Dose for Osteoporosis

400 mg orally once a day, 2 hours before or after meals for 14 days. Therapy is cyclical. Etidronate should be administered for the first 14 days of every 12 week cycle. Food, milk products, vitamins, minerals, and antacids should not be administered within two hours of a dose of etidronate.

Usual Adult Dose for Heterotopic Ossification - Spinal Cord Injury

20 mg/kg (ideal body weight) orally once a day, 2 hours before or after meals for 2 weeks (round dose to nearest 200 mg). This should be followed by 10 mg/kg/day (ideal body weight) orally for an additional 10 weeks (round dose to nearest 200 mg). Food, milk products, vitamins, minerals, and antacids should not be administered within two hours of a dose of etidronate.

Usual Adult Dose for Heterotopic Ossification - Total Hip Arthroplasty

20 mg/kg (ideal body weight) orally once a day, 2 hours before or after meals (round dose to nearest 200 mg) beginning 1 month prior to surgery and continuing for 3 months after surgery. Food, milk products, vitamins, minerals, and antacids should not be administered within two hours of a dose of etidronate.

Usual Pediatric Dose for Heterotopic Ossification - Spinal Cord Injury

Older than 1 year:

20 mg/kg (ideal body weight) orally once a day, 2 hours before or after meals for 2 weeks (round dose to nearest 200 mg). This should be followed by 10 mg/kg/day (ideal body weight) orally for an additional 10 weeks (round dose to nearest 200 mg). Food, milk products, vitamins, minerals, and antacids should not be administered within two hours of a dose of etidronate.

Usual Pediatric Dose for Heterotopic Ossification - Total Hip Arthroplasty

20 mg/kg (ideal body weight) orally once a day, 2 hours before or after meals (round dose to nearest 200 mg) beginning 1 month prior to surgery and continuing for 3 months after surgery. Food, milk products, vitamins, minerals, and antacids should not be administered within two hours of a dose of etidronate.

Renal Dose Adjustments

Use with caution in patients with serum creatinine between 2.5 to 4.9 mg/dl. It is recommended not to use etidronate in patients with serum creatinine of 5 mg/dl or higher.

Liver Dose Adjustments

Data not available

Dialysis

Data not available

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