Pill Identifier App

Esomeprazole Dosage

This dosage information may not include all the information needed to use Esomeprazole safely and effectively. See additional information for Esomeprazole.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for Gastroesophageal Reflux Disease

20 mg orally once a day for 4 to 8 weeks. It may be administered by the intravenous route if unable to use oral route.

Usual Adult Dose for Erosive Esophagitis

Healing: 20 to 40 mg orally once a day for 4 to 8 weeks. An additional 4 to 8 week course of therapy may be considered in patients not healed after initial treatment. It may be administered by the intravenous route if unable to use oral route.

Maintenance of healing: 20 mg orally once daily, for up to 6 months.

Usual Adult Dose for Helicobacter pylori Infection

40 mg orally once a day for 10 days along with amoxicillin 1000 mg and clarithromycin 500 mg orally twice a day for 10 days.

Usual Adult Dose for NSAID-Induced Gastric Ulcer

20 to 40 mg orally once daily for up to 6 months.

Usual Adult Dose for Zollinger-Ellison Syndrome

40 mg orally twice daily. Doses up to 240 mg daily have been used.

Usual Adult Dose for Pathological Hypersecretory Conditions

40 mg orally twice daily. Doses up to 240 mg daily have been used.

Usual Pediatric Dose for Gastroesophageal Reflux Disease

12 to 17 year olds: 20 mg once daily
Duration of therapy: 4 weeks

1 to 11 year olds: 10 mg once daily
Duration of therapy: For up to 8 weeks
Comments: Doses over 1 mg/kg/day have not been studied.

Usual Pediatric Dose for Erosive Esophagitis

Healing:
12 to 17 year olds: 20 or 40 mg once daily
Duration of therapy: 4 to 8 weeks
1 to 11 year olds:
-weight less than 20 kg: 10 mg once daily
-weight greater than or equal to 20 kg: 10 or 20 mg once daily
Duration of therapy: 8 weeks
Comments: Doses over 1 mg/kg/day have not been studied.

Due to acid-mediated GERD:
1 month to less than 1 year old:
-weight 3 kg to 5 kg: 2.5 mg once daily
-weight greater than 5 kg to 7.5 kg: 5 mg once daily
-weight greater than 7.5 kg to 12 kg: 10 mg once daily
Duration of therapy: For up to 6 weeks
Comments: Doses over 1.33 mg/kg/day have not been studied.

When oral therapy is not possible or appropriate (GERD with Erosive Esophagitis):
1 month to less than 1 year of age: 0.5 mg/kg once daily IV infusion over 10 minutes to 30 minutes
1 year to 17 years:
-weight less than 55 kg: 10 mg once daily IV infusion over 10 minutes to 30 minutes
-weight 55 kg or greater: 20 mg once daily IV infusion over 10 minutes to 30 minutes

Renal Dose Adjustments

No adjustments recommended

Liver Dose Adjustments

No dosage adjustment is recommended for patients with mild to moderate hepatic insufficiency (Child-Pugh class A and B). In patients with severe hepatic insufficiency (Child-Pugh class C), the maximum daily dose should not exceed 20 mg.

Precautions

Consult WARNINGS section for dosing related precautions.

Dialysis

Not dialyzable

Other Comments

Administration advice:
Oral Capsules:
-Take at least one hour before meals.
-Delayed-release capsule can be opened and mixed with 1 tablespoon of applesauce and swallowed immediately. Any unused mixture should be discarded. Mixing with other foods has not been evaluated and is not recommended.
Intravenous:
-The intravenous injection of esomeprazole should be administered over no less than 3 minutes. The intravenous infusion should be administered over 10 to 30 minutes.
-Treatment with esomeprazole injection is intended for short-term treatment (up to 10 days).

Storage requirements: Keep the delayed-release capsules in a tightly closed container.

Reconstitution/preparation techniques:
Delayed-release capsule:
-For patients with a nasogastric tube (NG), the delayed-release capsule can be opened, emptied into a 60 mL catheter tipped syringe, and mixed with 50 mL of water. Shake for 15 seconds, check for granules remaining in the tip, deliver contents through the NG tube, and flush the NG tube with water. Use mixture immediately after preparing. Rinse syringe with water after each use.
Oral suspension:
-Oral administration: Empty contents of 2.5 mg or 5 mg packet into 5 mL of water. Use 15 mL of water for the 10 mg, 20 mg and 40 mg packets. Stir, let thicken for 2 to 3 minutes, stir again, and drink within 30 minutes. Mix any remaining medicine with more water, stir, and drink.
-Nasogastric (NG) or gastric tube: Add 5 mL water to a catheter tipped syringe and add contents of a 2.5 mg or 5 mg packet. Use 10 mL water for the 10 mg, 20 mg and 40 mg packets. Shake the syringe and let thicken for 2 to 3 minutes. Shake syringe prior to injecting through the NG or gastric tube using a French size 6 or larger. Use mixture within 30 minutes. Refill the syringe with equal amount of water originally used, shake, and flush any remaining contents from NG or gastric tube.

Patient advice:
-Do not chew or crush capsules.
-Antacids can be used during treatment.

Hide
(web1)