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Duraclon Dosage

Generic name: clonidine hydrochloride
Dosage form: injection, solution

This dosage information does not include all the information needed to use Duraclon safely and effectively. See full prescribing information for Duraclon.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

The recommended starting dose of Duraclon for continuous epidural infusion is 30 μg/hr. Although dosage may be titrated up or down depending on pain relief and occurrence of adverse events, experience with dosage rates above 40 μg/hr is limited.

Familiarization with the continuous epidural infusion device is essential. Patients receiving epidural clonidine from a continuous infusion device should be closely monitored for the first few days to assess their response.

The 500 μg/mL (0.5 mg/mL) strength product must be diluted prior to use in 0.9% Sodium Chloride for Injection, U.S.P., to a final concentration of 100 μg/mL:


Volume of
Duraclon
500μg/mL		 Volume of 0.9%
Sodium Chloride
for Injection,
U.S.P.		 Resulting Final
Duraclon
Concentration
(100μg/mL)
1 mL 4 mL 500 μg/5 mL
2 mL 8 mL 1000 μg/10 mL
3 mL 12 mL 1500 μg/15 mL
4 mL 16 mL 2000 μg/20 mL
5 mL 20 mL 2500 μg/25 mL
6 mL 24 mL 3000 μg/30 mL
7 mL 28 mL 3500 μg/35 mL
8 mL 32 mL 4000 μg/40 mL
9 mL 36 mL 4500 μg/45 mL
10 mL 40 mL 5000 μg/50 mL

Renal Impairment: Dosage should be adjusted according to the degree of renal impairment, and patients should be carefully monitored. Since only a minimal amount of clonidine is removed during routine hemodialysis, there is no need to give supplemental clonidine following dialysis.

Duraclon must not  be used with a preservative.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

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